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Vgf VGF nerve growth factor inducible [ Mus musculus (house mouse) ]

Gene ID: 381677, updated on 21-Apr-2024

Summary

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Official Symbol
Vgfprovided by MGI
Official Full Name
VGF nerve growth factor inducibleprovided by MGI
Primary source
MGI:MGI:1343180
See related
Ensembl:ENSMUSG00000037428 AllianceGenome:MGI:1343180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1052
Summary
Enables neuropeptide hormone activity. Acts upstream of or within several processes, including glucose homeostasis; insulin secretion; and response to insulin. Predicted to be located in several cellular components, including Golgi apparatus; neuronal cell body; and secretory granule membrane. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human VGF (VGF nerve growth factor inducible). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 24.6), frontal lobe adult (RPKM 19.9) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.13 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137054156..137062205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137025301..137033351)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2-acylglycerol O-acyltransferase 2-A-like Neighboring gene predicted gene, 26989 Neighboring gene STARR-seq mESC enhancer starr_14633 Neighboring gene STARR-positive B cell enhancer ABC_E10359 Neighboring gene adaptor protein complex AP-1, sigma 1 Neighboring gene STARR-positive B cell enhancer ABC_E4796 Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. VGF is required for recovery after focal stroke. Gillis HL, et al. Exp Neurol, 2023 Apr. PMID 36682400
  2. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function. Lin WJ, et al. Transl Psychiatry, 2021 Jul 8. PMID 34238925, Free PMC Article
  3. VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models. Mizoguchi T, et al. Cell Mol Neurobiol, 2019 Aug. PMID 31037515
  4. Impaired Cerebellar Development in Mice Overexpressing VGF. Mizoguchi T, et al. Neurochem Res, 2019 Feb. PMID 30460640
  5. Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine in mice. Shen M, et al. Brain Res Bull, 2018 Oct. PMID 30316917

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis.
    Title: Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis.
  2. SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.
    Title: SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.
  3. Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
    Title: Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease.
  4. the roles of VGF using transgenic mice and its relevance to pathologies in major depressive disorder and schizophrenia, are discussed.
    Title: VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models.
  5. Results indicate that the rapid onset antidepressant-like actions of ketamine require VGF to regulate TrkB/mTOR/BICC1 signaling and AMPA receptor GluA1 phosphorylation.
    Title: Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine in mice.
  6. implicate VGF in the development of cerebellar granule cells via promoting MAPK signaling and motor function in the adult stage
    Title: Impaired Cerebellar Development in Mice Overexpressing VGF.
  7. Study demonstrates that VGF-overexpressing mice exhibit behavioral and morphological abnormalities that may be related to the mental illnesses such as schizophrenia and depression. These findings indicate that VGF may be implicated in the pathogenesis of several mental illnesses and in brain development.
    Title: Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF.
  8. Upregulation of VGF may be implicated in the pathophysiology of schizophrenia.
    Title: Sensorimotor gating deficits and effects of antipsychotics on the hyperactivity in VGF-overexpressing mice.
  9. conclude that the metabolic profile of germline VGF knockout mice is largely the result of VGF ablation in embryonic CNS neurons
    Title: Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weight.
  10. VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival.
    Title: Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide hormone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within generation of precursor metabolites and energy IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within generation of precursor metabolites and energy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within insulin secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to dietary excess IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to dietary excess IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sexual reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic signaling via neuropeptide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neurosecretory protein VGF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039385.1 → NP_001034474.1  neurosecretory protein VGF precursor

    See identical proteins and their annotated locations for NP_001034474.1

    Status: VALIDATED

    Source sequence(s)
    AC147986, CX236774
    Consensus CDS
    CCDS19760.1
    UniProtKB/Swiss-Prot
    Q0VGU4
    Related
    ENSMUSP00000048273.9, ENSMUST00000041543.9
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137054156..137062205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254624.2 → XP_030110484.1  neurosecretory protein VGF isoform X1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  2. XM_006504438.3 → XP_006504501.1  neurosecretory protein VGF isoform X1

    See identical proteins and their annotated locations for XP_006504501.1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Related
    ENSMUSP00000140815.2, ENSMUST00000190827.7
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  3. XM_006504436.3 → XP_006504499.1  neurosecretory protein VGF isoform X1

    See identical proteins and their annotated locations for XP_006504499.1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  4. XM_006504434.3 → XP_006504497.1  neurosecretory protein VGF isoform X1

    See identical proteins and their annotated locations for XP_006504497.1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  5. XM_017320939.2 → XP_017176428.1  neurosecretory protein VGF isoform X1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  6. XM_030254618.1 → XP_030110478.1  neurosecretory protein VGF isoform X1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  7. XM_030254622.1 → XP_030110482.1  neurosecretory protein VGF isoform X1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  8. XM_036165241.1 → XP_036021134.1  neurosecretory protein VGF isoform X1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  9. XM_006504435.3 → XP_006504498.1  neurosecretory protein VGF isoform X1

    See identical proteins and their annotated locations for XP_006504498.1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  10. XM_030254621.2 → XP_030110481.1  neurosecretory protein VGF isoform X1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA

  11. XM_017320938.2 → XP_017176427.1  neurosecretory protein VGF isoform X1

    UniProtKB/Swiss-Prot
    Q0VGU4
    Conserved Domains (1) summary
    PRK14086
    Location:24 → 248
    dnaA; chromosomal replication initiator protein DnaA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VGU4.1 GenPept UniProtKB/Swiss-Prot:Q0VGU4

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