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Cep135 centrosomal protein 135 [ Mus musculus (house mouse) ]

Gene ID: 381644, updated on 5-Mar-2024

Summary

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Official Symbol
Cep135provided by MGI
Official Full Name
centrosomal protein 135provided by MGI
Primary source
MGI:MGI:2681869
See related
Ensembl:ENSMUSG00000036403 AllianceGenome:MGI:2681869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cep4; Gm1044
Summary
Predicted to enable protein C-terminus binding activity. Predicted to be involved in centrosome cycle; positive regulation of establishment of protein localization; and positive regulation of non-motile cilium assembly. Predicted to be located in centriole and centrosome. Is expressed in node. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8. Orthologous to human CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 3.6), liver E14 (RPKM 2.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.3; 5 41.31 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76736495..76794313)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76588653..76646466)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 1 like Neighboring gene STARR-positive B cell enhancer ABC_E1053 Neighboring gene exocyst complex component 1 Neighboring gene capping protein inhibiting regulator of actin Neighboring gene predicted gene, 57768 Neighboring gene ribosomal protein L23a pseudogene Neighboring gene predicted gene, 34369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Mizuno S, et al. Sci Rep, 2015 Sep 8. PMID 26346620, Free PMC Article
  2. Pitchfork regulates primary cilia disassembly and left-right asymmetry. Kinzel D, et al. Dev Cell, 2010 Jul 20. PMID 20643351, Free PMC Article
  3. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Otto T, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923932, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis of Endothelial Cells in a Microtubule-Dependent Manner.
    Title: Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis of Endothelial Cells in a Microtubule-Dependent Manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC86039

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 135 kDa
Names
centrosomal protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199032.4 → NP_950197.1  centrosomal protein of 135 kDa

    See identical proteins and their annotated locations for NP_950197.1

    Status: VALIDATED

    Source sequence(s)
    AC127332
    Consensus CDS
    CCDS19365.1
    UniProtKB/Swiss-Prot
    Q6A030, Q6P5D4
    UniProtKB/TrEMBL
    Q3UVI6
    Related
    ENSMUSP00000112602.2, ENSMUST00000121979.8
    Conserved Domains (1) summary
    COG1196
    Location:199 → 934
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    76736495..76794313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535025.5 → XP_006535088.1  centrosomal protein of 135 kDa isoform X1

    UniProtKB/TrEMBL
    Q3UVI6
    Conserved Domains (3) summary
    COG1196
    Location:199 → 934
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:771 → 1121
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam13654
    Location:91 → 299
    AAA_32; AAA domain

  2. XM_036165238.1 → XP_036021131.1  centrosomal protein of 135 kDa isoform X3

    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 739
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006535028.4 → XP_006535091.1  centrosomal protein of 135 kDa isoform X4

    Conserved Domains (1) summary
    TIGR02168
    Location:1 → 676
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006535027.3 → XP_006535090.1  centrosomal protein of 135 kDa isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:13 → 742
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_389278.5 RNA Sequence

  2. XR_004942529.1 RNA Sequence

  3. XR_004942530.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5D4.1 GenPept UniProtKB/Swiss-Prot:Q6P5D4

Gene LinkOut

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