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Rxfp1 relaxin/insulin-like family peptide receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 381489, updated on 21-Apr-2024

Summary

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Official Symbol
Rxfp1provided by MGI
Official Full Name
relaxin/insulin-like family peptide receptor 1provided by MGI
Primary source
MGI:MGI:2682211
See related
Ensembl:ENSMUSG00000034009 AllianceGenome:MGI:2682211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lgr7; Gm1018
Summary
Enables hormone binding activity. Acts upstream of or within several processes, including lung connective tissue development; nipple morphogenesis; and parturition. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain and metanephros. Orthologous to human RXFP1 (relaxin family peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 9.6), cortex adult (RPKM 2.8) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 E3; 3 34.94 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79548910..79645258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79641600..79737951, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene electron transferring flavoprotein, dehydrogenase Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650 Neighboring gene STARR-seq mESC enhancer starr_08009 Neighboring gene transmembrane protein 144 Neighboring gene STARR-positive B cell enhancer ABC_E3438 Neighboring gene predicted gene, 26420 Neighboring gene STARR-seq mESC enhancer starr_08010 Neighboring gene STARR-seq mESC enhancer starr_08011 Neighboring gene STARR-seq mESC enhancer starr_08012 Neighboring gene golgi associated kinase 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction. Ng HH, et al. Front Physiol, 2021. PMID 34305630, Free PMC Article
  2. Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290. Kaftanovskaya EM, et al. J Endocr Soc, 2017 Jun. PMID 28825052, Free PMC Article
  3. Relaxin family peptides: structure-activity relationship studies. Patil NA, et al. Br J Pharmacol, 2017 May. PMID 27922185, Free PMC Article
  4. In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR Family. Petrie EJ, et al. Front Endocrinol (Lausanne), 2015. PMID 26441827, Free PMC Article
  5. Relaxin Affects Smooth Muscle Biophysical Properties and Mechanical Activity of the Female Mouse Colon. Squecco R, et al. Endocrinology, 2015 Dec. PMID 26360621

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
    Title: Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
  2. This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation.
    Title: Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
  3. No differences were found in RXFP1 expression related to aging.
    Title: Differential effects of relaxin deficiency on vascular aging in arteries of male mice.
  4. Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus.
    Title: Relaxin Affects Smooth Muscle Biophysical Properties and Mechanical Activity of the Female Mouse Colon.
  5. relaxin/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy
    Title: Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice.
  6. Rxfp1, Rxfp2, and Nr3c1 mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
    Title: Relaxin receptors 1 and 2 and nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) mRNAs are expressed in oral components of developing mice.
  7. maternal exposure to simazine causes disturbed relaxin signaling pathway and testicular dysfunction
    Title: Disturbed relaxin signaling pathway and testicular dysfunction in mouse offspring upon maternal exposure to simazine.
  8. H3 relaxin exerts antifibrotic actions via RXFP1 receptor
    Title: H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.
  9. The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 tumors.
    Title: Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis.
  10. Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY in regulating increased canonical Wnt signaling in prostate cancer.
    Title: Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hormone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lung connective tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myofibroblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nipple morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
relaxin receptor 1
Names
leucine-rich repeat-containing 7
leucine-rich repeat-containing G-protein coupled receptor 7
relaxin family peptide receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212452.3 → NP_997617.1  relaxin receptor 1 precursor

    See identical proteins and their annotated locations for NP_997617.1

    Status: VALIDATED

    Source sequence(s)
    AC122462, AC159281
    Consensus CDS
    CCDS17420.1
    UniProtKB/Swiss-Prot
    Q6R6I7, Q80UD3
    Related
    ENSMUSP00000077611.6, ENSMUST00000078527.13
    Conserved Domains (6) summary
    cd00112
    Location:27 → 62
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00116
    Location:147 → 331
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:110 → 127
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:128 → 151
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:422 → 681
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:151 → 210
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    79548910..79645258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252661.2 → XP_030108521.1  relaxin receptor 1 isoform X2

    Conserved Domains (5) summary
    sd00033
    Location:2 → 22
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:22 → 81
    LRR_8; Leucine rich repeat
    cd14964
    Location:279 → 303
    7tm_GPCRs; TM helix 1 [structural motif]
    NF033189
    Location:2 → 234
    internalin_A; class 1 internalin InlA
    cl28897
    Location:277 → 563
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006501629.3 → XP_006501692.1  relaxin receptor 1 isoform X1

    Conserved Domains (5) summary
    cd00112
    Location:27 → 62
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    sd00033
    Location:128 → 151
    LRR_RI; leucine-rich repeat [structural motif]
    cd15965
    Location:405 → 691
    7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors
    pfam13855
    Location:151 → 210
    LRR_8; Leucine rich repeat
    NF033189
    Location:126 → 334
    internalin_A; class 1 internalin InlA

  3. XM_030252662.2 → XP_030108522.1  relaxin receptor 1 isoform X3

    Conserved Domains (5) summary
    COG4886
    Location:9 → 145
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:20 → 43
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:43 → 102
    LRR_8; Leucine rich repeat
    cd14964
    Location:178 → 204
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:177 → 463
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6R6I7.1 GenPept UniProtKB/Swiss-Prot:Q6R6I7

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