Bpifb4 BPI fold containing family B, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpifb4provided by MGI
Official Full Name: BPI fold containing family B, member 4provided by MGI
Primary source: MGI:MGI:2685852
See related: Ensembl:ENSMUSG00000074665 AllianceGenome:MGI:2685852
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1006; Lplunc4
Summary: Predicted to enable lipid binding activity. Predicted to be located in cytoplasm and extracellular region. Orthologous to human BPIFB4 (BPI fold containing family B member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward ovary adult (RPKM 35.3) See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.99 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (153780137..153805772)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (153938217..153963852)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice.
Title: BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice.
The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.
Title: The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.
Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in the STHdh Cell Model of Huntington Disease.
Title: Longevity-Associated Variant of BPIFB4 Confers Neuroprotection in the STHdh Cell Model of Huntington Disease.
The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.
Title: The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.
RV-BPIFB4 acts directly on blood pressure homeostasis and may represent a novel biomarker of vascular dysfunction and hypertension.
Title: A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling.
LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism.
Title: LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism.

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General gene information

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Markers

D2Mit59 (e-PCR), detects polymorphism
- UniSTS:129454

D2Dcr108 (e-PCR), detects polymorphism
- UniSTS:507586

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BPI fold-containing family B member 4

Names: LBP / BPI / CETP family, N-terminal domain containing protein; Novel LBP/BPI/CETP family, N-terminal domain containing protein; ligand-binding protein RY2G5; long palate, lung and nasal epithelium carcinoma-associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034875.3 → NP_001030047.2 BPI fold-containing family B member 4 precursor

See identical proteins and their annotated locations for NP_001030047.2

Status: VALIDATED

Source sequence(s)

BX470156

Consensus CDS

CCDS16922.2

UniProtKB/Swiss-Prot

A2BGH0, Q3UPM5

Related

ENSMUSP00000105381.3, ENSMUST00000109759.9

Conserved Domains (2) summary

smart00329
Location:417 → 617

BPI2; BPI/LBP/CETP C-terminal domain

smart00328
Location:221 → 391

BPI1; BPI/LBP/CETP N-terminal domain