U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sp9 trans-acting transcription factor 9 [ Mus musculus (house mouse) ]

Gene ID: 381373, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Sp9provided by MGI
Official Full Name
trans-acting transcription factor 9provided by MGI
Primary source
MGI:MGI:3574660
See related
Ensembl:ENSMUSG00000068859 AllianceGenome:MGI:3574660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic limb morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including embryo ectoderm and limb epithelium. Orthologous to human SP9 (Sp9 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 7.9), frontal lobe adult (RPKM 7.8) and 5 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sp9 in Genome Data Viewer
Location:
2 C3; 2 43.52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73094809..73106115)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73271926..73275771)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Obg-like ATPase 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04836 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene STARR-positive B cell enhancer ABC_E2622 Neighboring gene secernin 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Sahara S, et al. Neural Dev, 2007 May 17. PMID 17509151, Free PMC Article
  2. Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons. Wei S, et al. J Comp Neurol, 2019 Dec 1. PMID 31070778
  3. Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration. Tao G, et al. Front Mol Neurosci, 2019. PMID 31001083, Free PMC Article
  4. Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Kawakami Y, et al. Development, 2004 Oct. PMID 15358670
  5. Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1. Oishi K, et al. Proc Natl Acad Sci U S A, 2009 Aug 4. PMID 19549840, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
    Title: Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
  2. our results demonstrate that Sp8 and Sp9 have crucial roles in regulating olfactory bulb interneuron development
    Title: Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
  3. SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression
    Title: SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
  4. Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/beta-catenin signaling during vertebrate limb outgrowth.
    Title: Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription factor Sp9
Names
buttonhead-like zinc finger transcription factor Sp9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005343.3 → NP_001005343.1  transcription factor Sp9

    See identical proteins and their annotated locations for NP_001005343.1

    Status: VALIDATED

    Source sequence(s)
    AL954713
    Consensus CDS
    CCDS16126.1
    UniProtKB/Swiss-Prot
    Q5QR89, Q64HY3
    Related
    ENSMUSP00000088322.6, ENSMUST00000090813.6
    Conserved Domains (4) summary
    sd00017
    Location:337 → 356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:392 → 414
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:378 → 401
    zf-H2C2_2; Zinc-finger double domain
    cd22549
    Location:19 → 333
    SP9_N; N-terminal domain of transcription factor Specificity Protein (SP) 9 and similar proteins

  2. NM_001409583.1 → NP_001396512.1  transcription factor Sp9

    Status: VALIDATED

    Source sequence(s)
    AL954713
    UniProtKB/Swiss-Prot
    Q5QR89, Q64HY3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    73094809..73106115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64HY3.1 GenPept UniProtKB/Swiss-Prot:Q64HY3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous