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Cacfd1 calcium channel flower domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 381356, updated on 11-Apr-2024

Summary

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Official Symbol
Cacfd1provided by MGI
Official Full Name
calcium channel flower domain containing 1provided by MGI
Primary source
MGI:MGI:1924317
See related
Ensembl:ENSMUSG00000015488 AllianceGenome:MGI:1924317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFwe; 5930434B04Rik
Summary
Predicted to be involved in vesicle-mediated transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human CACFD1 (calcium channel flower domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 21.6), ovary adult (RPKM 16.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cacfd1 in Genome Data Viewer
Location:
2 A3; 2 19.17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26899867..26911102)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27009855..27021090)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene REX4, 3'-5' exonuclease Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26819876-26820059 Neighboring gene predicted gene, 36649 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13 Neighboring gene STARR-positive B cell enhancer ABC_E7799 Neighboring gene STARR-positive B cell enhancer ABC_E5901 Neighboring gene STARR-positive B cell enhancer ABC_E7800 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 6 Neighboring gene STARR-seq mESC enhancer starr_03998 Neighboring gene ribosomal protein L6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Flower-deficient mice have reduced susceptibility to skin papilloma formation. Petrova E, et al. Dis Model Mech, 2012 Jul. PMID 22362363, Free PMC Article
  2. Cytotoxic granule endocytosis depends on the Flower protein. Chang HF, et al. J Cell Biol, 2018 Feb 5. PMID 29288152, Free PMC Article
  3. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium channel flower homolog
Names
calcium channel flower domain-containing protein 1
likely ortholog of H. sapiens chromosome 9 open reading frame 7 (C9orf7)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243239.1 → NP_001230168.1  calcium channel flower homolog isoform 2

    See identical proteins and their annotated locations for NP_001230168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK020041, AL845266
    Consensus CDS
    CCDS57160.1
    Related
    ENSMUSP00000109638.3, ENSMUST00000114005.9
    Conserved Domains (1) summary
    cl10918
    Location:34 → 106
    Cg6151-P; Uncharacterized conserved protein CG6151-P

  2. NM_001243240.1 → NP_001230169.1  calcium channel flower homolog isoform 3

    See identical proteins and their annotated locations for NP_001230169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK034046, AK038728, AL845266, BB262857, BB345271
    Consensus CDS
    CCDS57161.1
    Related
    ENSMUSP00000109637.2, ENSMUST00000114004.8
    Conserved Domains (1) summary
    cl10918
    Location:34 → 106
    Cg6151-P; Uncharacterized conserved protein CG6151-P

  3. NM_029862.4 → NP_084138.1  calcium channel flower homolog isoform 1

    See identical proteins and their annotated locations for NP_084138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK052562, AL845266
    Consensus CDS
    CCDS38086.1
    UniProtKB/Swiss-Prot
    A2AR22, A2AR23, A6PWX1, Q8BG21, Q8C9W0, Q8CC30, Q9CX69
    Related
    ENSMUSP00000109639.2, ENSMUST00000114006.8
    Conserved Domains (1) summary
    smart01077
    Location:34 → 142
    Cg6151-P; Uncharacterized conserved protein CG6151-P

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26899867..26911102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498159.4 → XP_006498222.1  calcium channel flower homolog isoform X1

    Conserved Domains (1) summary
    cl10918
    Location:34 → 100
    Cg6151-P; Uncharacterized conserved protein CG6151-P
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG21.1 GenPept UniProtKB/Swiss-Prot:Q8BG21

Gene LinkOut

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