Lonrf2 LON peptidase N-terminal domain and ring finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lonrf2provided by MGI
Official Full Name: LON peptidase N-terminal domain and ring finger 2provided by MGI
Primary source: MGI:MGI:1920209
See related: Ensembl:ENSMUSG00000048814 AllianceGenome:MGI:1920209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2900060P06Rik
Summary: Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 27.9), whole brain E14.5 (RPKM 19.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 17.17 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (38832750..38875768, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (38793669..38836687, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Title: LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D5S1969 (e-PCR), detects polymorphism
- UniSTS:15159

AI851349 (e-PCR)
- UniSTS:165074

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: LON peptidase N-terminal domain and RING finger protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029878.2 → NP_001025049.2 LON peptidase N-terminal domain and RING finger protein 2

Status: VALIDATED

Source sequence(s)

AC124699

Consensus CDS

CCDS14900.2

UniProtKB/TrEMBL

F6ZE64

Related

ENSMUSP00000117600.3, ENSMUST00000147695.9

Conserved Domains (5) summary

sd00006
Location:223 → 253

TPR; TPR repeat [structural motif]

pfam02190
Location:538 → 738

LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain

cd16513
Location:136 → 161

RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family

cd16514
Location:446 → 487

RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family

pfam13432
Location:27 → 90

TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

38832750..38875768 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028403.1: Suppressed sequence

Description

NM_028403.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: LONRF2 (GeneID:164832).