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Stum mechanosensory transduction mediator [ Mus musculus (house mouse) ]

Gene ID: 381310, updated on 5-Mar-2024

Summary

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Official Symbol
Stumprovided by MGI
Official Full Name
mechanosensory transduction mediatorprovided by MGI
Primary source
MGI:MGI:2138735
See related
Ensembl:ENSMUSG00000053963 AllianceGenome:MGI:2138735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm10001; 6330403A02Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human STUM (stum, mechanosensory transduction mediator homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 26.6), bladder adult (RPKM 22.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H4; 1 84.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180259938..180311199, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180432373..180483519, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3341 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene inositol 1,4,5-trisphosphate 3-kinase B Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182286358-182286687 Neighboring gene STARR-positive B cell enhancer ABC_E2591 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182296519-182296775 Neighboring gene STARR-positive B cell enhancer ABC_E1575 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182331940-182332241 Neighboring gene STARR-positive B cell enhancer ABC_E5870 Neighboring gene predicted gene, 39712 Neighboring gene STARR-positive B cell enhancer ABC_E5871 Neighboring gene STARR-positive B cell enhancer ABC_E5872 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182471419-182471720 Neighboring gene STARR-positive B cell enhancer ABC_E3342 Neighboring gene predicted gene, 31986 Neighboring gene STARR-seq mESC enhancer starr_03207 Neighboring gene poly (ADP-ribose) polymerase family, member 1 Neighboring gene microRNA 6904

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The stum gene is essential for mechanical sensing in proprioceptive neurons. Desai BS, et al. Science, 2014 Mar 14. PMID 24626929
  2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
  3. Molecular architecture of the developing mouse brain. La Manno G, et al. Nature, 2021 Aug. PMID 34321664
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein stum homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081227.2 → NP_001074696.1  protein stum homolog

    See identical proteins and their annotated locations for NP_001074696.1

    Status: VALIDATED

    Source sequence(s)
    AC121838, AK031805, BY637651, DN174476
    Consensus CDS
    CCDS48467.1
    UniProtKB/Swiss-Prot
    Q0VBF8
    UniProtKB/TrEMBL
    J3QP43
    Related
    ENSMUSP00000119782.2, ENSMUST00000136521.2
    Conserved Domains (1) summary
    pfam15795
    Location:44 → 127
    Spec3; Ectodermal ciliogenesis protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180259938..180311199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496914.5 → XP_006496977.1  protein stum homolog isoform X2

    UniProtKB/TrEMBL
    J3QP43
    Conserved Domains (1) summary
    pfam15795
    Location:44 → 127
    Spec3; Ectodermal ciliogenesis protein

  2. XM_006496913.5 → XP_006496976.1  protein stum homolog isoform X1

    UniProtKB/TrEMBL
    A0A1B0GS08, J3QP43
    Related
    ENSMUSP00000147747.2, ENSMUST00000211561.2
    Conserved Domains (1) summary
    pfam15795
    Location:44 → 127
    Spec3; Ectodermal ciliogenesis protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VBF8.1 GenPept UniProtKB/Swiss-Prot:Q0VBF8

Gene LinkOut

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