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Ifi211 interferon activated gene 211 [ Mus musculus (house mouse) ]

Gene ID: 381308, updated on 11-Apr-2024

Summary

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Official Symbol
Ifi211provided by MGI
Official Full Name
interferon activated gene 211provided by MGI
Primary source
MGI:MGI:3041120
See related
Ensembl:ENSMUSG00000026536 AllianceGenome:MGI:3041120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mnda; Ifi205b; ifi-205-B; A730048F03
Summary
The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression
Broad expression in liver E18 (RPKM 4.0), bladder adult (RPKM 2.7) and 15 other tissues See more
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Genomic context

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Location:
1 H3; 1 80.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173723907..173740650, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173896339..173913087, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03084 Neighboring gene myeloid nuclear differentiation antigen like Neighboring gene STARR-positive B cell enhancer ABC_E801 Neighboring gene predicted gene, 21031 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene interferon activated gene 203 Neighboring gene STARR-positive B cell enhancer ABC_E3335 Neighboring gene STARR-positive B cell enhancer ABC_E11109 Neighboring gene interferon activated gene 202B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene. Samanta H, et al. J Biol Chem, 1986 Sep 5. PMID 3017948
  2. Apoptosis-related gene expression profiles of mouse ESCs and maGSCs: role of Fgf4 and Mnda in pluripotent cell responses to genotoxicity. Khromov T, et al. PLoS One, 2012. PMID 23145002, Free PMC Article
  3. A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes. Tannenbaum CS, et al. J Leukoc Biol, 1993 May. PMID 7684766
  4. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
  5. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of Mnda in response to apoptosis and genotoxic stress is discussed.
    Title: Apoptosis-related gene expression profiles of mouse ESCs and maGSCs: role of Fgf4 and Mnda in pluripotent cell responses to genotoxicity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon-activable protein 205-B
Names
interferon-inducible protein p205-B
lipopolysaccharide-inducible
myeloid cell nuclear differentiation antigen
protein D3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033450.4 → NP_001028622.1  interferon-activable protein 205-B isoform 1

    See identical proteins and their annotated locations for NP_001028622.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC170584, AK152683, AK166217, AV250999, CJ067068
    Consensus CDS
    CCDS15532.1
    UniProtKB/Swiss-Prot
    P0DOV1
    UniProtKB/TrEMBL
    A0A1Z3MI21
    Related
    ENSMUSP00000009340.9, ENSMUST00000009340.10
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; Pyrin: a protein-protein interaction domain
    pfam02760
    Location:225 → 393
    HIN; HIN-200/IF120x domain

  2. NM_001301745.1 → NP_001288674.1  interferon-activable protein 205-B isoform 2

    See identical proteins and their annotated locations for NP_001288674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC170584, AK080485, AK152683, AK166217, AV250999, CJ067068
    UniProtKB/TrEMBL
    A0A1Z3MI21
    Conserved Domains (2) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:223 → 391
    HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173723907..173740650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166133.1 → XP_036022026.1  interferon-activable protein 205-B isoform X1

    Conserved Domains (1) summary
    cd08305
    Location:10 → 83
    Pyrin; a protein-protein interaction domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DOV1.1 GenPept UniProtKB/Swiss-Prot:P0DOV1

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