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Firrm FIGNL1 interacting regulator of recombination and mitosis [ Mus musculus (house mouse) ]

Gene ID: 381306, updated on 5-Mar-2024

Summary

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Official Symbol
Firrmprovided by MGI
Official Full Name
FIGNL1 interacting regulator of recombination and mitosisprovided by MGI
Primary source
MGI:MGI:3590554
See related
Ensembl:ENSMUSG00000041406 AllianceGenome:MGI:3590554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FLIP
Summary
Is expressed in testis and thyroid gland. Orthologous to human C1orf112 (chromosome 1 open reading frame 112). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.4), limb E14.5 (RPKM 5.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.2; 1 71.25 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163773409..163822377, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163945993..163994809, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02857 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene STARR-seq mESC enhancer starr_02858 Neighboring gene predicted gene, 51663 Neighboring gene kinesin-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_02859 Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E2015 Neighboring gene STARR-seq mESC enhancer starr_02860 Neighboring gene methyltransferase like 18 Neighboring gene selectin, endothelial cell

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases. van Dam S, et al. BMC Genomics, 2012 Oct 6. PMID 23039964, Free PMC Article
  2. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
    Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
  2. BC055324 gene is strongly co-expressed with known cancer-associated genes and with genes involved in the cell cycle.
    Title: GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC65590

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FIGNL1-interacting regulator of recombination and mitosis
Names
FIDGETIN-like-1 interacting protein
POLO1-associating protein
uncharacterized protein C1orf112 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357049.1 → NP_001343978.1  FIGNL1-interacting regulator of recombination and mitosis isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110499, AC158964, AK141661
    Consensus CDS
    CCDS87908.1
    Related
    ENSMUSP00000095101.4, ENSMUST00000097493.10
    Conserved Domains (1) summary
    pfam14868
    Location:234 → 779
    DUF4487; Domain of unknown function (DUF4487)

  2. NM_201364.2 → NP_958752.1  FIGNL1-interacting regulator of recombination and mitosis isoform 1

    See identical proteins and their annotated locations for NP_958752.1

    Status: VALIDATED

    Source sequence(s)
    AC110499, AC158964, BC055324
    Consensus CDS
    CCDS35752.1
    UniProtKB/Swiss-Prot
    Q3TQQ9, Q3UR98, Q5RKU3, Q7TMQ3
    Related
    ENSMUSP00000043143.7, ENSMUST00000045876.8
    Conserved Domains (1) summary
    pfam14868
    Location:234 → 779
    DUF4487; Domain of unknown function (DUF4487)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    163773409..163822377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496909.5 → XP_006496972.2  FIGNL1-interacting regulator of recombination and mitosis isoform X1

    Conserved Domains (1) summary
    pfam14868
    Location:234 → 779
    DUF4487; Domain of unknown function (DUF4487)

RNA

  1. XR_004942956.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TQQ9.2 GenPept UniProtKB/Swiss-Prot:Q3TQQ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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