Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp2b4provided by MGI
Official Full Name: ATPase, Ca++ transporting, plasma membrane 4provided by MGI
Primary source: MGI:MGI:88111
See related: Ensembl:ENSMUSG00000026463 AllianceGenome:MGI:88111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pmca4
Summary: Enables scaffold protein binding activity and sodium channel regulator activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of cardiac muscle hypertrophy in response to stress. Located in T-tubule and sperm flagellum. Part of protein-containing complex. Is expressed in several structures, including bladder; heart; intestine wall; liver; and nervous system. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 55.6), genital fat pad adult (RPKM 33.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.95 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (133630416..133728755, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (133702674..133801059, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia.
Title: PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia.
Plasma membrane Ca(2+) ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca(2+) homeostasis in mice.
Title: Plasma membrane Ca(2+) ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca(2+) homeostasis in mice.
PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis.
Title: PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis.
the role of PMCA4 in the regulation of blood pressure was examined.
Title: Acute inhibition of PMCA4, but not global ablation, reduces blood pressure and arterial contractility via a nNOS-dependent mechanism.
study provides evidence for the therapeutic potential of targeting PMCA4 to improve VEGF-based pro-angiogenic interventions. This goal will require the development of refined, highly selective versions of ATA, or the identification of novel PMCA4 inhibitors.
Title: Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion.
PMCA4 co-ordinates both Ca2+ and NO signaling in mammalian sperm, to control sperm motility.
Title: Plasma membrane calcium ATPase 4 (PMCA4) co-ordinates calcium and nitric oxide signaling in regulating murine sperm functional activity.
the ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility
Title: An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.
PMCA4 has no discernible role in normal renal Ca2+ handling as no urinary Ca2+ wasting was observed. Further investigation of the exact role of PMCA4 in the distal convoluted tubule and connecting tubule is required
Title: Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?
PMCA4 regulates the development of cardiac hypertrophy and provide proof of principle for a therapeutic approach to treat this condition.
Title: The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy.
Electron microscopy demonstrated Pmca4 localization in distal nephron cells at both the basolateral membrane and intracellular perinuclear compartments but not submembranous vesicles
Title: Ultrastructural and immunohistochemical localization of plasma membrane Ca2+-ATPase 4 in Ca2+-transporting epithelia.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion export	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to acetylcholine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of arginine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of citrulline biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-cysteine S-nitrosylation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sodium ion transmembrane transport	IC Inferred by Curator more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to hydrostatic pressure	ISO Inferred from Sequence Orthology more info
involved_in urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasma membrane calcium-transporting ATPase 4

NP_001161421.1

EC 7.2.2.10

NP_001408007.1

EC 7.2.2.10

NP_001408008.1

EC 7.2.2.10

NP_001408009.1

EC 7.2.2.10

NP_998781.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167949.3 → NP_001161421.1 plasma membrane calcium-transporting ATPase 4 isoform a

See identical proteins and their annotated locations for NP_001161421.1

Status: VALIDATED

Source sequence(s)

AC124338, AC157924

Consensus CDS

CCDS48365.1

UniProtKB/TrEMBL

D1FNM8, F7AAP4

Related

ENSMUSP00000047978.8, ENSMUST00000048953.14

Conserved Domains (2) summary

TIGR01517
Location:16 → 1053

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1090 → 1127

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
NM_001421078.1 → NP_001408007.1 plasma membrane calcium-transporting ATPase 4 isoform c

Status: VALIDATED

Source sequence(s)

AC124338, AC157924

UniProtKB/TrEMBL

E9Q828
NM_001421079.1 → NP_001408008.1 plasma membrane calcium-transporting ATPase 4 isoform d

Status: VALIDATED

Source sequence(s)

AC124338, AC157924
NM_001421080.1 → NP_001408009.1 plasma membrane calcium-transporting ATPase 4 isoform e

Status: VALIDATED

Source sequence(s)

AC124338, AC157924
NM_213616.5 → NP_998781.1 plasma membrane calcium-transporting ATPase 4 isoform b

See identical proteins and their annotated locations for NP_998781.1

Status: VALIDATED

Source sequence(s)

AC124338, AC157924

Consensus CDS

CCDS15298.1

UniProtKB/Swiss-Prot

Q32ME1, Q6Q477

UniProtKB/TrEMBL

D1FNM9

Related

ENSMUSP00000133187.3, ENSMUST00000165602.9

Conserved Domains (2) summary

TIGR01517
Location:16 → 1053

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1090 → 1135

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal