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Tmem237 transmembrane protein 237 [ Mus musculus (house mouse) ]

Gene ID: 381259, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem237provided by MGI
Official Full Name
transmembrane protein 237provided by MGI
Primary source
MGI:MGI:2138365
See related
Ensembl:ENSMUSG00000038079 AllianceGenome:MGI:2138365
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm972; Als2cr4
Summary
Involved in cilium assembly and regulation of Wnt signaling pathway. Located in cone photoreceptor outer segment; photoreceptor connecting cilium; and rod photoreceptor outer segment. Is expressed in alimentary system; gallbladder; lower urinary tract; and reproductive system. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 13.3), CNS E18 (RPKM 7.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.3; 1 29.2 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59139743..59159567, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59100584..59120422, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_01029 Neighboring gene predicted gene 29018 Neighboring gene predicted gene, 25502 Neighboring gene STARR-seq mESC enhancer starr_01030 Neighboring gene membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59219938-59220121 Neighboring gene predicted gene, 19125 Neighboring gene alsin Rho guanine nucleotide exchange factor Neighboring gene STARR-positive B cell enhancer ABC_E1993

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HIF-1α-activated TMEM237 promotes hepatocellular carcinoma progression via the NPHP1/Pyk2/ERK pathway. Chen T, et al. Cell Mol Life Sci, 2023 Apr 11. PMID 37041420
  2. Deciphering the structure and function of Als2cr4 in the mouse retina. Zuniga FI, et al. Invest Ophthalmol Vis Sci, 2010 Sep. PMID 20375344, Free PMC Article
  3. TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Huang L, et al. Am J Hum Genet, 2011 Dec 9. PMID 22152675, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cone photoreceptor outer segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rod photoreceptor outer segment IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 237
Names
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033449.2 → NP_001028621.1  transmembrane protein 237 isoform 1

    See identical proteins and their annotated locations for NP_001028621.1

    Status: VALIDATED

    Source sequence(s)
    AC133162
    Consensus CDS
    CCDS14983.1
    UniProtKB/Swiss-Prot
    Q3V0J1
    Related
    ENSMUSP00000092522.4, ENSMUST00000094917.10
    Conserved Domains (1) summary
    pfam15383
    Location:148 → 391
    TMEM237; Transmembrane protein 237

  2. NM_001037812.3 → NP_001032901.1  transmembrane protein 237 isoform 2

    See identical proteins and their annotated locations for NP_001032901.1

    Status: VALIDATED

    Source sequence(s)
    AK167733, BM899705
    Consensus CDS
    CCDS14984.1
    UniProtKB/Swiss-Prot
    Q3V0J1
    Related
    ENSMUSP00000084745.5, ENSMUST00000087475.11
    Conserved Domains (1) summary
    pfam15383
    Location:138 → 381
    TMEM237; Transmembrane protein 237

  3. NM_001361413.1 → NP_001348342.1  transmembrane protein 237 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK133112, BM899705, BY097381
    Consensus CDS
    CCDS87834.1
    UniProtKB/Swiss-Prot
    B2RVK7, Q3TIS2, Q3V0J1
    Related
    ENSMUSP00000139823.2, ENSMUST00000186794.7
    Conserved Domains (1) summary
    pfam15383
    Location:162 → 405
    TMEM237; Transmembrane protein 237

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59139743..59159567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496096.5 → XP_006496159.1  transmembrane protein 237 isoform X1

    Conserved Domains (1) summary
    pfam15383
    Location:141 → 384
    TMEM237; Transmembrane protein 237

  2. XM_006496097.5 → XP_006496160.1  transmembrane protein 237 isoform X2

    Conserved Domains (1) summary
    pfam15383
    Location:133 → 376
    TMEM237; Transmembrane protein 237
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V0J1.1 GenPept UniProtKB/Swiss-Prot:Q3V0J1

Gene LinkOut

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