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Top6bl TOP6B like initiator of meiotic double strand breaks [ Mus musculus (house mouse) ]

Gene ID: 381196, updated on 3-Apr-2024

Summary

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Official Symbol
Top6blprovided by MGI
Official Full Name
TOP6B like initiator of meiotic double strand breaksprovided by MGI
Primary source
MGI:MGI:2685806
See related
Ensembl:ENSMUSG00000071691 AllianceGenome:MGI:2685806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm960; TOPOVIBL
Summary
Predicted to enable DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in meiotic DNA double-strand break formation and reciprocal meiotic recombination. Predicted to be located in chromosome. Is expressed in ovary; primary oocyte; secondary oocyte; and testis. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human C11orf80 (chromosome 11 open reading frame 80). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 1.6), whole brain E14.5 (RPKM 0.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Top6bl in Genome Data Viewer
Location:
19 A; 19 4.08 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4675758..4748753, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4625734..4698713, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene microRNA 6986 Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene STARR-positive B cell enhancer ABC_E1967 Neighboring gene predicted gene 21992 Neighboring gene RNA binding motif protein 4B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Nore A, et al. Nat Commun, 2022 Nov 17. PMID 36396648, Free PMC Article
  2. Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles. Nguyen NMP, et al. Am J Hum Genet, 2018 Nov 1. PMID 30388401, Free PMC Article
  3. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Robert T, et al. Science, 2016 Feb 26. PMID 26917764
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
    Title: TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type 2 DNA topoisomerase 6 subunit B-like
Names
type 2 DNA topoisomerase VI subunit B-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033447.4 → NP_001028619.3  type 2 DNA topoisomerase 6 subunit B-like

    Status: VALIDATED

    Source sequence(s)
    AC128739, AC147618
    Consensus CDS
    CCDS57129.1
    Related
    ENSMUSP00000136515.2, ENSMUST00000177696.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4675758..4748753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248638.4 → XP_011246940.1  type 2 DNA topoisomerase 6 subunit B-like isoform X5

    UniProtKB/TrEMBL
    A0A182DWE7
    Conserved Domains (1) summary
    pfam15091
    Location:274 → 644
    DUF4554; Domain of unknown function (DUF4554)

  2. XM_011248637.4 → XP_011246939.1  type 2 DNA topoisomerase 6 subunit B-like isoform X4

    UniProtKB/TrEMBL
    A0A182DWE7
    Conserved Domains (1) summary
    pfam15091
    Location:274 → 677
    DUF4554; Domain of unknown function (DUF4554)

  3. XM_011248636.4 → XP_011246938.1  type 2 DNA topoisomerase 6 subunit B-like isoform X3

    UniProtKB/TrEMBL
    A0A182DWE7
    Conserved Domains (1) summary
    pfam15091
    Location:274 → 681
    DUF4554; Domain of unknown function (DUF4554)

  4. XM_011248634.4 → XP_011246936.1  type 2 DNA topoisomerase 6 subunit B-like isoform X1

    UniProtKB/TrEMBL
    A0A182DWE7
    Conserved Domains (1) summary
    pfam15091
    Location:274 → 714
    DUF4554; Domain of unknown function (DUF4554)

  5. XM_036161617.1 → XP_036017510.1  type 2 DNA topoisomerase 6 subunit B-like isoform X6

    UniProtKB/TrEMBL
    A0A182DWE7
    Conserved Domains (1) summary
    pfam15091
    Location:274 → 658
    DUF4554; Domain of unknown function (DUF4554)

  6. XM_011248635.4 → XP_011246937.1  type 2 DNA topoisomerase 6 subunit B-like isoform X2

    UniProtKB/TrEMBL
    A0A182DWE7
    Conserved Domains (1) summary
    pfam15091
    Location:274 → 714
    DUF4554; Domain of unknown function (DUF4554)

  7. XM_011248639.4 → XP_011246941.1  type 2 DNA topoisomerase 6 subunit B-like isoform X7

    Conserved Domains (1) summary
    pfam15091
    Location:274 → 542
    DUF4554; Domain of unknown function (DUF4554)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
J3QMY9.2 GenPept UniProtKB/Swiss-Prot:J3QMY9

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