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Greb1l growth regulation by estrogen in breast cancer-like [ Mus musculus (house mouse) ]

Gene ID: 381157, updated on 11-Apr-2024

Summary

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Official Symbol
Greb1lprovided by MGI
Official Full Name
growth regulation by estrogen in breast cancer-likeprovided by MGI
Primary source
MGI:MGI:3576497
See related
Ensembl:ENSMUSG00000042942 AllianceGenome:MGI:3576497
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4095
Summary
Acts upstream of or within animal organ development and paramesonephric duct development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; liver; tail unsegmented mesenchyme; thymus; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 5.2), adrenal adult (RPKM 2.3) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Greb1l in Genome Data Viewer
Location:
18 A1; 18 5.0 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10324933..10562945)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10324933..10562945)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_43791 Neighboring gene STARR-seq mESC enhancer starr_43793 Neighboring gene RAE1 RNA export 1 homolog pseudogene Neighboring gene nuclear transport factor 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_43798 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:10532920-10533103 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene small nuclear ribonucleoprotein D1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Sanna-Cherchi S, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100090, Free PMC Article
  2. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. De Tomasi L, et al. Am J Hum Genet, 2017 Nov 2. PMID 29100091, Free PMC Article
  3. Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Chal J, et al. Development, 2018 Mar 19. PMID 29555813
  4. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.
    Title: Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA4095

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mesonephric duct development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within paramesonephric duct development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GREB1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083628.1 → NP_001077097.1  GREB1-like protein

    See identical proteins and their annotated locations for NP_001077097.1

    Status: PROVISIONAL

    Source sequence(s)
    AC102441, AC124740, AEKQ02056206
    Consensus CDS
    CCDS37736.1
    UniProtKB/Swiss-Prot
    B9EJV3, Q5DTN6
    Related
    ENSMUSP00000049003.9, ENSMUST00000048977.16
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1913
    GREB1; Gene regulated by oestrogen in breast cancer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    10324933..10562945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526068.4 → XP_006526131.1  GREB1-like protein isoform X1

    See identical proteins and their annotated locations for XP_006526131.1

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1956
    GREB1; Gene regulated by oestrogen in breast cancer

  2. XM_006526069.3 → XP_006526132.1  GREB1-like protein isoform X3

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1610
    GREB1; Gene regulated by oestrogen in breast cancer

  3. XM_011246970.4 → XP_011245272.1  GREB1-like protein isoform X1

    See identical proteins and their annotated locations for XP_011245272.1

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1956
    GREB1; Gene regulated by oestrogen in breast cancer

  4. XM_030250521.2 → XP_030106381.1  GREB1-like protein isoform X2

    UniProtKB/Swiss-Prot
    B9EJV3, Q5DTN6
    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1913
    GREB1; Gene regulated by oestrogen in breast cancer

  5. XM_036161197.1 → XP_036017090.1  GREB1-like protein isoform X4

    Conserved Domains (1) summary
    pfam15782
    Location:1 → 1011
    GREB1; Gene regulated by oestrogen in breast cancer
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9EJV3.1 GenPept UniProtKB/Swiss-Prot:B9EJV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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