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Arhgef33 Rho guanine nucleotide exchange factor 33 [ Mus musculus (house mouse) ]

Gene ID: 381112, updated on 30-Apr-2024

Summary

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Official Symbol
Arhgef33provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 33provided by MGI
Primary source
MGI:MGI:2685787
See related
Ensembl:ENSMUSG00000054901 AllianceGenome:MGI:2685787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm941
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human ARHGEF33 (Rho guanine nucleotide exchange factor 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 8.0) and testis adult (RPKM 1.4) See more
Orthologs
human all
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Genomic context

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Location:
17 E3; 17 50.63 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80614354..80740926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80306923..80433497)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene DExH-box helicase 57 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene MORN repeat containing 2 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190 Neighboring gene STARR-seq mESC enhancer starr_43312 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-seq mESC enhancer starr_43313 Neighboring gene STARR-positive B cell enhancer ABC_E8924 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene alkaline phosphatase, intestinal pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Hall EA, et al. Am J Hum Genet, 2017 May 4. PMID 28413018, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 33
Names
DH and coiled-coil domain-containing protein ENSP00000381780 homolog
Rho guanine nucleotide exchange factor (GEF) 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145452.1 → NP_001138924.1  rho guanine nucleotide exchange factor 33

    See identical proteins and their annotated locations for NP_001138924.1

    Status: PROVISIONAL

    Source sequence(s)
    AC161447, AI848431, AK053944, BB628974, BE653884, BE654086, BE950677, CK793318, CK793330
    Consensus CDS
    CCDS50189.1
    UniProtKB/Swiss-Prot
    Q8BW86
    Related
    ENSMUSP00000063284.6, ENSMUST00000068175.6
    Conserved Domains (1) summary
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80614354..80740926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524512.5 → XP_006524575.1  rho guanine nucleotide exchange factor 33 isoform X3

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:259 → 426
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  2. XM_030249876.2 → XP_030105736.1  rho guanine nucleotide exchange factor 33 isoform X4

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:259 → 426
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  3. XM_030249875.2 → XP_030105735.1  rho guanine nucleotide exchange factor 33 isoform X3

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:259 → 426
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  4. XM_006524509.4 → XP_006524572.1  rho guanine nucleotide exchange factor 33 isoform X1

    See identical proteins and their annotated locations for XP_006524572.1

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  5. XM_006524511.4 → XP_006524574.1  rho guanine nucleotide exchange factor 33 isoform X2

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  6. XM_006524510.4 → XP_006524573.1  rho guanine nucleotide exchange factor 33 isoform X1

    See identical proteins and their annotated locations for XP_006524573.1

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  7. XM_006524514.5 → XP_006524577.1  rho guanine nucleotide exchange factor 33 isoform X7

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  8. XM_006524515.5 → XP_006524578.1  rho guanine nucleotide exchange factor 33 isoform X8

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  9. XM_030249880.2 → XP_030105740.1  rho guanine nucleotide exchange factor 33 isoform X9

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  10. XM_006524516.5 → XP_006524579.1  rho guanine nucleotide exchange factor 33 isoform X9

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  11. XM_006524519.5 → XP_006524582.1  rho guanine nucleotide exchange factor 33 isoform X10

    See identical proteins and their annotated locations for XP_006524582.1

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  12. XM_006524518.5 → XP_006524581.1  rho guanine nucleotide exchange factor 33 isoform X10

    See identical proteins and their annotated locations for XP_006524581.1

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  13. XM_006524513.5 → XP_006524576.1  rho guanine nucleotide exchange factor 33 isoform X5

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  14. XM_017317545.3 → XP_017173034.1  rho guanine nucleotide exchange factor 33 isoform X11

    UniProtKB/Swiss-Prot
    Q8BW86
    Conserved Domains (1) summary
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  15. XM_030249877.2 → XP_030105737.1  rho guanine nucleotide exchange factor 33 isoform X6

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  16. XM_030249879.2 → XP_030105739.1  rho guanine nucleotide exchange factor 33 isoform X6

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  17. XM_006524523.5 → XP_006524586.1  rho guanine nucleotide exchange factor 33 isoform X11

    See identical proteins and their annotated locations for XP_006524586.1

    UniProtKB/Swiss-Prot
    Q8BW86
    Conserved Domains (1) summary
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  18. XM_006524520.5 → XP_006524583.1  rho guanine nucleotide exchange factor 33 isoform X10

    See identical proteins and their annotated locations for XP_006524583.1

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  19. XM_006524524.5 → XP_006524587.1  rho guanine nucleotide exchange factor 33 isoform X11

    See identical proteins and their annotated locations for XP_006524587.1

    UniProtKB/Swiss-Prot
    Q8BW86
    Conserved Domains (1) summary
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  20. XM_006524522.5 → XP_006524585.1  rho guanine nucleotide exchange factor 33 isoform X12

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  21. XM_011246520.4 → XP_011244822.1  rho guanine nucleotide exchange factor 33 isoform X13

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  22. XM_006524525.5 → XP_006524588.1  rho guanine nucleotide exchange factor 33 isoform X14

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  23. XM_030249883.2 → XP_030105743.1  rho guanine nucleotide exchange factor 33 isoform X15

    Conserved Domains (2) summary
    pfam07111
    Location:42 → 127
    HCR; Alpha helical coiled-coil rod protein (HCR)
    cl02571
    Location:277 → 444
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BW86.3 GenPept UniProtKB/Swiss-Prot:Q8BW86

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