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Prickle4 prickle planar cell polarity protein 4 [ Mus musculus (house mouse) ]

Gene ID: 381104, updated on 5-Mar-2024

Summary

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Official Symbol
Prickle4provided by MGI
Official Full Name
prickle planar cell polarity protein 4provided by MGI
Primary source
MGI:MGI:2685785
See related
Ensembl:ENSMUSG00000096549 AllianceGenome:MGI:2685785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm939
Summary
Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization; heart development; and muscle structure development. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Orthologous to human PRICKLE4 (prickle planar cell polarity protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach adult (RPKM 9.2), CNS E18 (RPKM 4.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 23.87 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47999399..48005834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47688474..47694910, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20517 Neighboring gene mediator complex subunit 20 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E4218 Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene STARR-seq mESC enhancer starr_42721 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene predicted gene, 46579

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis. Ru J, et al. Invest Ophthalmol Vis Sci, 2020 Nov 2. PMID 33141892, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables muscle alpha-actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prickle-like protein 4
Names
prickle homolog 4
translocase of outer mitochondrial membrane 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290337.1 → NP_001277266.1  prickle-like protein 4

    See identical proteins and their annotated locations for NP_001277266.1

    Status: VALIDATED

    Source sequence(s)
    AC139214, BQ042537, BX525727
    Consensus CDS
    CCDS70823.1
    UniProtKB/TrEMBL
    D3Z6Q6, F6ZPB0
    Related
    ENSMUSP00000108925.2, ENSMUST00000113300.8
    Conserved Domains (3) summary
    cd09340
    Location:124 → 181
    LIM1_Testin_like; The first LIM domain of Testin-like family
    cd09341
    Location:187 → 241
    LIM2_Testin_like; The second LIM domain of Testin-like family
    cd09828
    Location:1 → 116
    PET_OEBT; The PET domain of overexpressed breast tumor protein (OEBT)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47999399..48005834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160670.1 → XP_036016563.1  prickle-like protein 4 isoform X1

    Conserved Domains (2) summary
    cd09340
    Location:124 → 181
    LIM1_Testin_like; The first LIM domain of Testin-like family
    cd09828
    Location:1 → 116
    PET_OEBT; The PET domain of overexpressed breast tumor protein (OEBT)
Nucleotide Protein Strain
Heading Accession and Version

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