Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnph1provided by MGI
Official Full Name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1provided by MGI
Primary source: MGI:MGI:3039376
See related: Ensembl:ENSMUSG00000040658 AllianceGenome:MGI:3039376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rcl
Summary: Predicted to enable deoxyribonucleoside 5'-monophosphate N-glycosidase activity and protein homodimerization activity. Predicted to be involved in allantoin metabolic process; dGMP catabolic process; and positive regulation of cell growth. Predicted to act upstream of or within nucleotide metabolic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in cap mesenchyme and male associated reproductive structure. Orthologous to human DNPH1 (2'-deoxynucleoside 5'-phosphate N-hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 21.5), liver E14 (RPKM 8.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46807715..46810544)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46496789..46499618)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in amide catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in dGMP catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in deoxyribonucleoside monophosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleoside monophosphate catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5-hydroxymethyl-dUMP N-hydrolase

Names: c-Myc-responsive protein Rcl; deoxyribonucleoside 5'-monophosphate N-glycosidase; putative c-Myc-responsive

NP_997044.2

EC 3.2.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.