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H2-Eb2 histocompatibility 2, class II antigen E beta2 [ Mus musculus (house mouse) ]

Gene ID: 381091, updated on 8-Feb-2024

Summary

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Official Symbol
H2-Eb2provided by MGI
Official Full Name
histocompatibility 2, class II antigen E beta2provided by MGI
Primary source
MGI:MGI:95902
See related
Ensembl:ENSMUSG00000067341 AllianceGenome:MGI:95902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ia5; Ia-5; H-2Eb2; Iebeta2; A130038H09Rik
Summary
Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to human HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 5.4), thymus adult (RPKM 2.6) and 4 other tissues See more
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34544477..34560384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34325503..34341410)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene histocompatibility 2, class II antigen A, alpha Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene histocompatibility 2, class II antigen E beta Neighboring gene STARR-positive B cell enhancer ABC_E8670 Neighboring gene STARR-positive B cell enhancer ABC_E8919 Neighboring gene STARR-seq mESC enhancer starr_42429 Neighboring gene STARR-positive B cell enhancer ABC_E769 Neighboring gene histocompatibility 2, class II antigen E alpha Neighboring gene STARR-positive B cell enhancer ABC_E11639 Neighboring gene butyrophilin-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription. Braunstein NS, et al. EMBO J, 1986 Oct. PMID 3780666, Free PMC Article
  2. Mouse MHC class II gene E beta 2 is closely related to E beta and to HLA-DR beta. Denaro M, et al. Immunogenetics, 1985. PMID 2989167
  3. The Forgotten: Identification and Functional Characterization of MHC Class II Molecules H2-Eb2 and RT1-Db2. Monzón-Casanova E, et al. J Immunol, 2016 Feb 1. PMID 26740108
  4. Epitopes of the NS3 protein of hepatitis C virus: recognition in HLA-DR4 transgenic mice. Eckels DD, et al. Immunol Cell Biol, 2002 Feb. PMID 11869368
  5. Recruitment of multiple alleles within the Eb recombinational hotspot in murine MHC. Saha BK. Mamm Genome, 1993. PMID 8268654

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables T cell receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables polysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MHC class II protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histocompatibility 2, class II antigen E beta2
Names
H-2 class II histocompatibility antigen E-a/k beta-2
MHC class II E-beta-2
MHC class II antigen E beta2
MHC class II antigen beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033978.3 → NP_001029150.1  histocompatibility 2, class II antigen E beta2

    See identical proteins and their annotated locations for NP_001029150.1

    Status: VALIDATED

    Source sequence(s)
    AK137912, CR974457
    Consensus CDS
    CCDS28646.1
    UniProtKB/TrEMBL
    Q3U060, Q3UUV9
    Related
    ENSMUSP00000056814.9, ENSMUST00000050325.10
    Conserved Domains (2) summary
    cd05766
    Location:125 → 218
    IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
    pfam00969
    Location:42 → 115
    MHC_II_beta; Class II histocompatibility antigen, beta domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34544477..34560384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524489.5 → XP_006524552.1  histocompatibility 2, class II antigen E beta2 isoform X1

    See identical proteins and their annotated locations for XP_006524552.1

    UniProtKB/TrEMBL
    Q3U060
    Conserved Domains (3) summary
    pfam00969
    Location:42 → 115
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    pfam06364
    Location:226 → 282
    DUF1068; Protein of unknown function (DUF1068)
    cl11960
    Location:125 → 218
    Ig; Immunoglobulin domain

  2. XM_006524490.5 → XP_006524553.1  histocompatibility 2, class II antigen E beta2 isoform X2

    See identical proteins and their annotated locations for XP_006524553.1

    UniProtKB/TrEMBL
    Q3U060
    Conserved Domains (2) summary
    pfam00969
    Location:42 → 115
    MHC_II_beta; Class II histocompatibility antigen, beta domain
    cl11960
    Location:125 → 218
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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