Npw neuropeptide W [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npwprovided by MGI
Official Full Name: neuropeptide Wprovided by MGI
Primary source: MGI:MGI:2685781
See related: Ensembl:ENSMUSG00000071230 AllianceGenome:MGI:2685781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm935
Summary: Orthologs of this gene express a preproprotein that is processed into a neuropeptide ligand for two G-protein coupled receptors in the central nervous system. The neuropeptide is thought to directly or indirectly regulate feeding, weight regulation, and pain response. The preproprotein is translated using a non-AUG initiation codon. [provided by RefSeq, Jul 2008]
Expression: Biased expression in stomach adult (RPKM 51.2) and lung adult (RPKM 38.0) See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.45 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24876303..24877526, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24657329..24658552, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The neuropeptide W (NPW) mRNA quickly elevated in the early differentiation (7-14 days) of ATDC5 cells, while NPW and neuropeptides B/W receptor 1 (GPR7) mRNA were reduced during the late stage (14-21 days) of differentiation.
Title: Neuropeptide W regulates proliferation and differentiation of ATDC5: Possible involvement of GPR7 activation, PKA and PKC-dependent signalling cascades.
the effect and underlying mechanisms of NGF/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported.
Title: Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo.
These results indicate that the NPW/NPBWR1 system could play a critical role in the gating of stressful stimuli during exposure to novel environments.
Title: Mesolimbic neuropeptide W coordinates stress responses under novel environments.
These findings suggest that the physiological role of NPW varies depending on the age of the mice.
Title: Neuropeptide W modulation of gastric vagal afferent mechanosensitivity: Impact of age and sex.
These data suggest that the dorsomedial hypothalamus neurons that transiently co-express NPW and NPY in the peri-weaning period might play a role in regulating energy homeostasis during postnatal development.
Title: Transient expression of neuropeptide W in postnatal mouse hypothalamus--a putative regulator of energy homeostasis.
these studies indicated an inconsistency between plasma and gastric NPW expression in response to nutrient ingestion, suggesting food induced gastric NPW expression may play a more important role locally
Title: Gastric neuropeptide W is regulated by meal-related nutrients.
Neuropeptide W modulates gastric vagal afferent activity
Title: Modulation of murine gastric vagal afferent mechanosensitivity by neuropeptide W.
Study indicates that NPW may play an important role in the regulation of feeding and energy metabolism.
Title: Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state.
a non-AUG translation initiation site is used to express the mouse Npw preproprotein
Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: neuropeptide W

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099664.2 → NP_001093134.1 neuropeptide W preproprotein

Status: VALIDATED

Source sequence(s)

AC154566

Consensus CDS

CCDS50017.1

UniProtKB/TrEMBL

F7B5D6

Related

ENSMUSP00000093200.5, ENSMUST00000095544.6

Conserved Domains (1) summary

pfam15180
Location:34 → 140

NPBW; Neuropeptides B and W