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Abca17 ATP-binding cassette, sub-family A member 17 [ Mus musculus (house mouse) ]

Gene ID: 381072, updated on 11-Apr-2024

Summary

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Official Symbol
Abca17provided by MGI
Official Full Name
ATP-binding cassette, sub-family A member 17provided by MGI
Primary source
MGI:MGI:3625331
See related
Ensembl:ENSMUSG00000035435 AllianceGenome:MGI:3625331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Acts upstream of or within neutral lipid metabolic process. Located in endoplasmic reticulum. Is expressed in lymph node; stomach; testis; and thyroid gland. Orthologous to human ABCA17P (ATP binding cassette subfamily A member 17, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.8), lung adult (RPKM 1.7) and 7 other tissues See more
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Genomic context

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Location:
17 A3.3; 17 12.35 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24483231..24570079, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24264257..24352058, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cyclin F Neighboring gene STARR-seq mESC enhancer starr_42081 Neighboring gene microRNA 5134 Neighboring gene STARR-seq mESC enhancer starr_42082 Neighboring gene microRNA 6965 Neighboring gene STARR-seq mESC enhancer starr_42083 Neighboring gene STARR-positive B cell enhancer ABC_E9436 Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene STARR-seq mESC enhancer starr_42084 Neighboring gene predicted gene, 25618 Neighboring gene RIKEN cDNA D330041H03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes. Morales CR, et al. Histol Histopathol, 2012 Mar. PMID 22237709
  2. Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism. Ban N, et al. Biochem J, 2005 Jul 15. PMID 15810880, Free PMC Article
  3. The human ortholog of the rodent testis-specific ABC transporter Abca17 is a ubiquitously expressed pseudogene (ABCA17P) and shares a common 5' end with ABCA3. Piehler AP, et al. BMC Mol Biol, 2006 Sep 12. PMID 16968533, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutral lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family A member 17
Names
ATP-binding cassette, sub-family A (ABC1), member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031621.3 → NP_001026792.2  ATP-binding cassette sub-family A member 17

    See identical proteins and their annotated locations for NP_001026792.2

    Status: VALIDATED

    Source sequence(s)
    AC117577
    Consensus CDS
    CCDS37485.1
    UniProtKB/Swiss-Prot
    E9PX95, Q4H4D7
    Related
    ENSMUSP00000112538.2, ENSMUST00000121226.8
    Conserved Domains (1) summary
    TIGR01257
    Location:209 → 1684
    rim_protein; retinal-specific rim ABC transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24483231..24570079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317534.3 → XP_017173023.1  ATP-binding cassette sub-family A member 17 isoform X2

    Conserved Domains (1) summary
    TIGR01257
    Location:209 → 1677
    rim_protein; retinal-specific rim ABC transporter

  2. XM_017317532.3 → XP_017173021.1  ATP-binding cassette sub-family A member 17 isoform X1

    UniProtKB/Swiss-Prot
    E9PX95, Q4H4D7
    Conserved Domains (1) summary
    TIGR01257
    Location:209 → 1684
    rim_protein; retinal-specific rim ABC transporter

  3. XM_017317536.3 → XP_017173025.1  ATP-binding cassette sub-family A member 17 isoform X3

    Conserved Domains (1) summary
    TIGR01257
    Location:209 → 1645
    rim_protein; retinal-specific rim ABC transporter

  4. XM_006524484.5 → XP_006524547.1  ATP-binding cassette sub-family A member 17 isoform X8

    Conserved Domains (1) summary
    TIGR01257
    Location:44 → 1108
    rim_protein; retinal-specific rim ABC transporter

  5. XM_006524482.5 → XP_006524545.1  ATP-binding cassette sub-family A member 17 isoform X7

    See identical proteins and their annotated locations for XP_006524545.1

    Conserved Domains (1) summary
    TIGR01257
    Location:51 → 1115
    rim_protein; retinal-specific rim ABC transporter

  6. XM_017317540.2 → XP_017173029.1  ATP-binding cassette sub-family A member 17 isoform X9

    Conserved Domains (1) summary
    TIGR01257
    Location:1 → 1048
    rim_protein; retinal-specific rim ABC transporter

  7. XM_017317537.3 → XP_017173026.1  ATP-binding cassette sub-family A member 17 isoform X4

    Conserved Domains (1) summary
    TIGR01257
    Location:209 → 1560
    rim_protein; retinal-specific rim ABC transporter

  8. XM_017317539.3 → XP_017173028.1  ATP-binding cassette sub-family A member 17 isoform X5

    Conserved Domains (1) summary
    TIGR01257
    Location:209 → 1314
    rim_protein; retinal-specific rim ABC transporter

  9. XM_006524481.5 → XP_006524544.1  ATP-binding cassette sub-family A member 17 isoform X6

    Conserved Domains (1) summary
    TIGR01257
    Location:209 → 1246
    rim_protein; retinal-specific rim ABC transporter

RNA

  1. XR_001782084.3 RNA Sequence

  2. XR_001782083.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PX95.1 GenPept UniProtKB/Swiss-Prot:E9PX95

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