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Mix23 mitochondrial matrix import factor 23 [ Mus musculus (house mouse) ]

Gene ID: 381045, updated on 5-Mar-2024

Summary

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Official Symbol
Mix23provided by MGI
Official Full Name
mitochondrial matrix import factor 23provided by MGI
Primary source
MGI:MGI:2146423
See related
Ensembl:ENSMUSG00000075229 AllianceGenome:MGI:2146423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc58; A930007B11Rik
Summary
Located in mitochondrion. Orthologous to human MIX23 (mitochondrial matrix import factor 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 11.7), CNS E11.5 (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 25.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35892030..35912488)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36071660..36092118)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5540 Neighboring gene WD repeat domain 5B Neighboring gene family with sequence similarity 162, member A Neighboring gene STARR-seq mESC enhancer starr_40755 Neighboring gene STARR-seq mESC enhancer starr_40756 Neighboring gene STARR-seq mESC enhancer starr_40757 Neighboring gene predicted gene, 41450 Neighboring gene STARR-seq mESC enhancer starr_40758 Neighboring gene cystatin A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC36453

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein MIX23
Names
coiled-coil domain containing 58
coiled-coil domain-containing protein 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159421.1 → NP_001152893.1  protein MIX23 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK135450, BB686073, CB949450, CF617453, CJ094333
    Consensus CDS
    CCDS49838.1
    UniProtKB/TrEMBL
    E9Q4B5
    Related
    ENSMUSP00000131929.2, ENSMUST00000163352.9
    Conserved Domains (1) summary
    pfam09774
    Location:9 → 92
    Cid2; Caffeine-induced death protein 2

  2. NM_001159422.1 → NP_001152894.1  protein MIX23 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK135450, AV583692, BB686073
    Consensus CDS
    CCDS49839.1
    UniProtKB/TrEMBL
    F8WJI3
    Related
    ENSMUSP00000097520.5, ENSMUST00000099937.6
    Conserved Domains (1) summary
    pfam09774
    Location:1 → 124
    Cid2; Caffeine-induced death protein 2

  3. NM_198645.2 → NP_941047.1  protein MIX23 isoform 1

    See identical proteins and their annotated locations for NP_941047.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK135450, BB686073, CB949450, CF617453
    Consensus CDS
    CCDS28147.1
    UniProtKB/Swiss-Prot
    Q3UXM5, Q8R3Q6
    Related
    ENSMUSP00000125874.2, ENSMUST00000164916.9
    Conserved Domains (1) summary
    pfam09774
    Location:10 → 134
    Cid2; Caffeine-induced death protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35892030..35912488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3Q6.1 GenPept UniProtKB/Swiss-Prot:Q8R3Q6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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