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Begain brain-enriched guanylate kinase-associated [ Mus musculus (house mouse) ]

Gene ID: 380785, updated on 9-May-2024

Summary

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Official Symbol
Begainprovided by MGI
Official Full Name
brain-enriched guanylate kinase-associatedprovided by MGI
Primary source
MGI:MGI:3044626
See related
Ensembl:ENSMUSG00000040867 AllianceGenome:MGI:3044626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm897
Summary
Involved in regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within evoked excitatory postsynaptic potential. Located in glutamatergic synapse and presynapse. Is expressed in central nervous system; eye; and lip. Orthologous to human BEGAIN (brain enriched guanylate kinase associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 24.5), frontal lobe adult (RPKM 23.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 59.98 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108998107..109034168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (109032181..109068242, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5353 Neighboring gene STARR-seq mESC enhancer starr_33252 Neighboring gene predicted gene, 22079 Neighboring gene STARR-seq mESC enhancer starr_33253 Neighboring gene tryptophanyl-tRNA synthetase1 Neighboring gene WD repeat domain 25 Neighboring gene STARR-seq mESC enhancer starr_33254 Neighboring gene STARR-seq mESC enhancer starr_33255 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:110295982-110296239 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110312387-110312688 Neighboring gene STARR-positive B cell enhancer mm9_chr12:110313106-110313407 Neighboring gene predicted gene, 52002 Neighboring gene macrophage migration inhibitory factor, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_33259 Neighboring gene STARR-seq mESC enhancer starr_33260 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:110676232-110676385 Neighboring gene delta like non-canonical Notch ligand 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Begain gene marks the centromeric boundary of the imprinted region on mouse chromosome 12. Tierling S, et al. Mamm Genome, 2009 Sep-Oct. PMID 19641963
  2. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. Katano T, et al. eNeuro, 2016 Sep-Oct. PMID 27785460, Free PMC Article
  3. Klf14 is an imprinted transcription factor that regulates placental growth. Koppes E, et al. Placenta, 2019 Dec. PMID 31675530, Free PMC Article
  4. ZFP57 dictates allelic expression switch of target imprinted genes. Jiang W, et al. Proc Natl Acad Sci U S A, 2021 Feb 2. PMID 33500348, Free PMC Article
  5. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within evoked excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
brain-enriched guanylate kinase-associated protein
Names
brain-enriched guanylate kinase-associated; brain-enriched guanylate kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163175.1 → NP_001156647.1  brain-enriched guanylate kinase-associated protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AK158915, BC080282
    Consensus CDS
    CCDS56862.1
    UniProtKB/TrEMBL
    A0A087WQY4, F8WIG2
    Related
    ENSMUSP00000140393.3, ENSMUST00000190647.3
    Conserved Domains (2) summary
    COG1196
    Location:21 → 143
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:510 → 618
    Pilt; Protein incorporated later into Tight Junctions

  2. NM_001374200.1 → NP_001361129.1  brain-enriched guanylate kinase-associated protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140111
    Conserved Domains (2) summary
    TIGR02168
    Location:56 → 170
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15453
    Location:540 → 648
    Pilt; Protein incorporated later into Tight Junctions

  3. NM_001374201.1 → NP_001361130.1  brain-enriched guanylate kinase-associated protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140111
    Conserved Domains (2) summary
    COG1196
    Location:19 → 141
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:508 → 616
    Pilt; Protein incorporated later into Tight Junctions

  4. NM_001374202.1 → NP_001361131.1  brain-enriched guanylate kinase-associated protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140111
    Consensus CDS
    CCDS88401.1
    UniProtKB/TrEMBL
    A0A5F8MPR2
    Related
    ENSMUSP00000159072.2, ENSMUST00000239108.2
    Conserved Domains (2) summary
    COG1196
    Location:5 → 137
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:504 → 612
    Pilt; Protein incorporated later into Tight Junctions

  5. NM_001374203.1 → NP_001361132.1  brain-enriched guanylate kinase-associated protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140111
    Consensus CDS
    CCDS88400.1
    UniProtKB/Swiss-Prot
    Q68EF6
    Conserved Domains (2) summary
    COG1196
    Location:2 → 124
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:491 → 599
    Pilt; Protein incorporated later into Tight Junctions

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    108998107..109034168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244128.3 → XP_011242430.1  brain-enriched guanylate kinase-associated protein isoform X3

    See identical proteins and their annotated locations for XP_011242430.1

    Conserved Domains (2) summary
    TIGR02168
    Location:37 → 151
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15453
    Location:521 → 629
    Pilt; Protein incorporated later into Tight Junctions

  2. XM_006516044.3 → XP_006516107.1  brain-enriched guanylate kinase-associated protein isoform X4

    See identical proteins and their annotated locations for XP_006516107.1

    UniProtKB/Swiss-Prot
    Q68EF6
    Related
    ENSMUSP00000158999.2, ENSMUST00000238841.2
    Conserved Domains (2) summary
    COG1196
    Location:2 → 124
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:491 → 599
    Pilt; Protein incorporated later into Tight Junctions

  3. XM_006516041.5 → XP_006516104.1  brain-enriched guanylate kinase-associated protein isoform X2

    Conserved Domains (2) summary
    TIGR02168
    Location:50 → 164
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15453
    Location:534 → 642
    Pilt; Protein incorporated later into Tight Junctions

  4. XM_006516040.5 → XP_006516103.1  brain-enriched guanylate kinase-associated protein isoform X1

    Conserved Domains (2) summary
    TIGR02168
    Location:54 → 168
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15453
    Location:538 → 646
    Pilt; Protein incorporated later into Tight Junctions
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EF6.2 GenPept UniProtKB/Swiss-Prot:Q68EF6

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