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Kcnh4 potassium voltage-gated channel, subfamily H (eag-related), member 4 [ Mus musculus (house mouse) ]

Gene ID: 380728, updated on 30-Apr-2024

Summary

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Official Symbol
Kcnh4provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 4provided by MGI
Primary source
MGI:MGI:2156184
See related
Ensembl:ENSMUSG00000035355 AllianceGenome:MGI:2156184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BEC2
Summary
Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be integral component of plasma membrane. Orthologous to human KCNH4 (potassium voltage-gated channel subfamily H member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 10.0), CNS E18 (RPKM 9.3) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 63.57 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100631204..100650941, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100740378..100760115, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100575167-100575276 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene RAB5C, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E3022 Neighboring gene STARR-positive B cell enhancer ABC_E8452 Neighboring gene hypocretin Neighboring gene STARR-positive B cell enhancer ABC_E5278 Neighboring gene GH3 domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Cui Y, et al. Genomics, 2001 Dec. PMID 11735219
  2. A gene expression resource generated by genome-wide lacZ profiling in the mouse. Tuck E, et al. Dis Model Mech, 2015 Nov. PMID 26398943, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily H member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081194.2 → NP_001074663.1  potassium voltage-gated channel subfamily H member 4

    See identical proteins and their annotated locations for NP_001074663.1

    Status: VALIDATED

    Source sequence(s)
    AL591469, BC150990
    Consensus CDS
    CCDS36334.1
    UniProtKB/TrEMBL
    A2A5F7
    Related
    ENSMUSP00000102984.2, ENSMUST00000107361.9
    Conserved Domains (6) summary
    cd00038
    Location:556 → 676
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:42 → 133
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:244 → 486
    Ion_trans; Ion transport protein
    pfam07885
    Location:426 → 480
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 135
    PAS_9; PAS domain
    cl21462
    Location:864 → 902
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100631204..100650941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533646.4 → XP_006533709.1  potassium voltage-gated channel subfamily H member 4 isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:177 → 620
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK11753
    Location:583 → 671
    PRK11753; cAMP-activated global transcriptional regulator CRP
    PRK13557
    Location:41 → 134
    PRK13557; histidine kinase; Provisional

  2. XM_036156819.1 → XP_036012712.1  potassium voltage-gated channel subfamily H member 4 isoform X2

    Conserved Domains (4) summary
    PLN03192
    Location:61 → 255
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03247
    Location:347 → 638
    PHA03247; large tegument protein UL36; Provisional
    cl00047
    Location:213 → 304
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl21462
    Location:499 → 537
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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