Cnrip1 cannabinoid receptor interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnrip1provided by MGI
Official Full Name: cannabinoid receptor interacting protein 1provided by MGI
Primary source: MGI:MGI:1917505
See related: Ensembl:ENSMUSG00000044629 AllianceGenome:MGI:1917505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C2orf32; 1500041B16Rik; 3110054C06Rik; 5330437A18Rik
Summary: Predicted to enable protein C-terminus binding activity and type 1 cannabinoid receptor binding activity. Predicted to be involved in negative regulation of signaling receptor activity. Located in myelin sheath. Is expressed in mesonephros. Orthologous to human CNRIP1 (cannabinoid receptor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 66.2), whole brain E14.5 (RPKM 33.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A2; 11 9.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (17001859..17029372)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (17051859..17079372)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cannabinoid receptor interacting protein 1a interacts with myristoylated Galphai N terminus via a unique gapped beta-barrel structure.
Title: Cannabinoid receptor interacting protein 1a interacts with myristoylated Gα(i) N terminus via a unique gapped β-barrel structure.
Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription.
Title: Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription.
Pharmacological blockade or genetic deletion of anterior piriform cortex (aPC)-CB1 receptors specifically impaired the retrieval of conditioned odor preference. Interestingly, expression of conditioned odor aversion was unaffected by local CB1 receptor blockade, indicating that the role of aPC endocannabinoid signaling is selective for retrieval of appetitive memory.
Title: CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory.
these data demonstrate that blocking CB1 receptors leads to upregulation of miR-30e-5p and down regulation of DLL4 in adipose tissue macrophages, which in turn suppress DLL4-Notch signaling-induced polarization of inflammatory Th1 cells and adipocyte energy storage.
Title: Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells.
peripubertal stress affects CB1 gene expression in the nucleus accumbens shell
Title: Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala.
Ddata indicate that cannabinoid receptor-interacting protein 1a enhances hippocampal cannabinoid type 1 receptor signaling in vivo.
Title: Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus.
These studies demonstrate a novel role for CRIP1a in agonist-driven CB1 R cell surface regulation postulated to occur by two mechanisms: 1) attenuating internalization that is agonist-mediated, but not that in the absence of exogenous agonists, and 2) biased agonist-dependent trafficking of de novo synthesized receptor to the cell surface
Title: Cannabinoid receptor interacting protein suppresses agonist-driven CB(1) receptor internalization and regulates receptor replenishment in an agonist-biased manner.
Endogenous levels of CRIP1a modulate CB1R-mediated signal transduction by facilitating a Gi/o protein subtype preference for Gi1 and Gi2, accompanied by an overall suppression of G-protein-mediated signaling in neuronal cells.
Title: Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.
CRIP1a appears to act as a broad negative regulator of CB1 receptor function
Title: Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables type 1 cannabinoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 cannabinoid receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CB1 cannabinoid receptor-interacting protein 1

Names: CRIP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.