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Acss3 acyl-CoA synthetase short-chain family member 3 [ Mus musculus (house mouse) ]

Gene ID: 380660, updated on 21-Apr-2024

Summary

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Official Symbol
Acss3provided by MGI
Official Full Name
acyl-CoA synthetase short-chain family member 3provided by MGI
Primary source
MGI:MGI:2685720
See related
Ensembl:ENSMUSG00000035948 AllianceGenome:MGI:2685720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm874; 8430416H19Rik
Summary
Predicted to enable acetate-CoA ligase activity; butyrate-CoA ligase activity; and propionate-CoA ligase activity. Located in mitochondrion. Is expressed in central nervous system; nose; and respiratory system. Orthologous to human ACSS3 (acyl-CoA synthetase short chain family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 7.7), subcutaneous fat pad adult (RPKM 6.9) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D1; 10 55.66 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (106769375..106959622, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (106933514..107123761, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 Neighboring gene RIKEN cDNA 4930532I03 gene Neighboring gene STARR-seq mESC enhancer starr_27779 Neighboring gene nucleolin pseudogene Neighboring gene STARR-seq mESC enhancer starr_27780 Neighboring gene sulfotransferase family, cytosolic, 1C, member 2 pseudogene Neighboring gene predicted gene, 18040 Neighboring gene PRP38 pre-mRNA processing factor 38 domain containing A pseudogene Neighboring gene STARR-seq mESC enhancer starr_27781 Neighboring gene predicted gene, 24745 Neighboring gene predicted gene, 29674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.
    Title: ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables butyrate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables propionate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-CoA synthetase short-chain family member 3, mitochondrial
Names
acetate--CoA ligase 3
propionate--CoA ligase
NP_001136276.1
NP_941038.2
XP_030101011.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142804.2 → NP_001136276.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001136276.1

    Status: VALIDATED

    Source sequence(s)
    AC111014, AC121946, AC134457
    Consensus CDS
    CCDS48688.1
    UniProtKB/Swiss-Prot
    Q14DH7, Q8BZX0
    Related
    ENSMUSP00000128209.2, ENSMUST00000165067.9
    Conserved Domains (1) summary
    cd05967
    Location:57 → 674
    PrpE; Propionyl-CoA synthetase (PrpE)

  2. NM_198636.4 → NP_941038.2  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_941038.2

    Status: VALIDATED

    Source sequence(s)
    AC121946, AC134457
    Consensus CDS
    CCDS24159.1
    UniProtKB/Swiss-Prot
    Q14DH7
    Related
    ENSMUSP00000040823.5, ENSMUST00000044668.5
    Conserved Domains (1) summary
    cl17068
    Location:67 → 482
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    106769375..106959622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245151.1 → XP_030101011.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd05967
    Location:1 → 571
    PrpE; Propionyl-CoA synthetase (PrpE)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14DH7.2 GenPept UniProtKB/Swiss-Prot:Q14DH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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