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KIFC3 kinesin family member C3 [ Homo sapiens (human) ]

Gene ID: 3801, updated on 7-Apr-2024

Summary

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Official Symbol
KIFC3provided by HGNC
Official Full Name
kinesin family member C3provided by HGNC
Primary source
HGNC:HGNC:6326
See related
Ensembl:ENSG00000140859 MIM:604535; AllianceGenome:HGNC:6326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression
Broad expression in kidney (RPKM 11.2), testis (RPKM 9.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16q21
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (57758217..57862858, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63553374..63658232, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57792129..57837165, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 7 Neighboring gene MTCH2 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57767533-57768510 Neighboring gene uncharacterized LOC107984852 Neighboring gene Sharpr-MPRA regulatory region 7942 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57777601-57778101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57790901-57791540 Neighboring gene katanin regulatory subunit B1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57808554-57809132 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57809711-57810289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57817648-57818250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57818251-57818852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57819145-57819804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57820464-57821122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57821123-57821781 Neighboring gene microRNA 6772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57828526-57829344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57829345-57830161 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57835346-57836022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57836700-57837376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57850615-57851160 Neighboring gene uncharacterized LOC388282 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57858755-57859256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57859257-57859756 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57869467-57869968 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:57869969-57870468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57871284-57872020 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57879667-57880550 Neighboring gene RNA, U6 small nuclear 20, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57880551-57881432 Neighboring gene NANOG hESC enhancer GRCh37_chr16:57907038-57907565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10917 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57917491-57918038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57918039-57918586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7538 Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:57945302-57946008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57972707-57973534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57973535-57974362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:57998489-57998988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10918 Neighboring gene sperm microtubule inner protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIFC3 promotes mitotic progression and integrity of the central spindle in cytokinesis. Nachbar J, et al. Cell Cycle, 2014. PMID 24275865, Free PMC Article
  2. Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. De S, et al. Cancer Res, 2009 Oct 15. PMID 19789344
  3. Characterization of a novel C-kinesin (KIFC3) abundantly expressed in vertebrate retina and RPE. Hoang E, et al. Exp Eye Res, 1999 Jul. PMID 10375449
  4. Cloning of a novel C-terminal kinesin (KIFC3) that maps to human chromosome 16q13-q21 and thus is a candidate gene for Bardet-Biedl syndrome. Hoang EH, et al. Genomics, 1998 Sep 1. PMID 9782090
  5. Limited T-cell receptor diversity in liver-infiltrating lymphocytes from patients with primary biliary cirrhosis. Diu A, et al. J Autoimmun, 1993 Oct. PMID 8240664

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIFC3 Regulates the progression and metastasis of gastric cancer via Notch1 pathway.
    Title: KIFC3 Regulates the progression and metastasis of gastric cancer via Notch1 pathway.
  2. Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.
    Title: Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.
  3. KIFC3 activity becomes the main driving force of centrosome cohesion to prevent premature spindle formation after linker dissolution as it counteracts the increasing EG5-driven pushing forces
    Title: The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly.
  4. Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C was much lower than the expression of dynactin subunits DCTN1 and DCTN3, in both sporadic amyotrophic lateral sclerosis and healthy cases
    Title: Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis.
  5. Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47.
    Title: Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions.
  6. KIFC3 may guide free microtubules to their destination at the bridge and/or may slide and crosslink central bridge microtubules in order to stage the cells for abscission.
    Title: KIFC3 promotes mitotic progression and integrity of the central spindle in cytokinesis.
  7. KifC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes.
    Title: Identification of the kinesin KifC3 as a new player for positioning of peroxisomes and other organelles in mammalian cells.
  8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  10. High expression of KIFC3 is associated with docetaxel resistance in breast cancer.
    Title: Overexpression of kinesins mediates docetaxel resistance in breast cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34694, DKFZp686D23201

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception TAS
Traceable Author Statement
more info
 PubMed 
involved_in zonula adherens maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in zonula adherens IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIFC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130099.1 → NP_001123571.1  kinesin-like protein KIFC3 isoform 3

    See identical proteins and their annotated locations for NP_001123571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
    Source sequence(s)
    AK291737, BC008014, DC381406
    Consensus CDS
    CCDS45494.1
    UniProtKB/TrEMBL
    B7Z8X8
    Related
    ENSP00000396399.2, ENST00000421376.6
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  2. NM_001130100.2 → NP_001123572.1  kinesin-like protein KIFC3 isoform 2

    See identical proteins and their annotated locations for NP_001123572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 4.
    Source sequence(s)
    AB209290, AK291737, BC008014, DA989120
    Consensus CDS
    CCDS45493.1
    UniProtKB/TrEMBL
    B7Z808
    Related
    ENSP00000401696.2, ENST00000445690.7
    Conserved Domains (2) summary
    COG1196
    Location:172 → 444
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:443 → 770
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  3. NM_001318710.2 → NP_001305639.1  kinesin-like protein KIFC3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC092118, AK296995, BC041132, BE384068
    Consensus CDS
    CCDS81989.1
    UniProtKB/TrEMBL
    B7Z808
    Related
    ENSP00000442008.1, ENST00000541240.5
    Conserved Domains (3) summary
    COG1196
    Location:194 → 466
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:465 → 792
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam08961
    Location:153 → 186
    NRBF2; Nuclear receptor-binding factor 2, autophagy regulator

  4. NM_001318711.2 → NP_001305640.1  kinesin-like protein KIFC3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the coding region and uses an alternate start codon, compared to variant 4. It encodes isoform 5, which has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    AC092118, AK291737, AK299431, BC041132
    UniProtKB/TrEMBL
    B7Z5U4, H3BMZ5
    Related
    ENSP00000454615.2, ENST00000561524.6
    Conserved Domains (3) summary
    cd01366
    Location:385 → 712
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:393 → 710
    Kinesin; Kinesin motor domain
    cl12013
    Location:119 → 306
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. NM_001318712.2 → NP_001305641.1  kinesin-like protein KIFC3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the coding region and uses an alternate start codon, compared to variant 4. It encodes isoform 6, which has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    AK296995, AK302743, BC041132, BC047051
    Consensus CDS
    CCDS81988.1
    UniProtKB/TrEMBL
    B7Z808, F5H3M2
    Related
    ENSP00000438805.2, ENST00000540079.6
    Conserved Domains (2) summary
    cd01366
    Location:341 → 668
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:40 → 338
    SMC_N; RecF/RecN/SMC N terminal domain

  6. NM_001318713.2 → NP_001305642.1  kinesin-like protein KIFC3 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon and uses an alternate splice site in the coding region, compared to variant 4. It encodes isoform 7, which is shorter than isoform 4.
    Source sequence(s)
    AK296995, AK303021, BC041132, BC047051, DC402000
    Consensus CDS
    CCDS81987.1
    UniProtKB/TrEMBL
    B7Z896, B7Z8X8
    Related
    ENSP00000444012.1, ENST00000543930.5
    Conserved Domains (2) summary
    cd01366
    Location:304 → 628
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:3 → 301
    SMC_N; RecF/RecN/SMC N terminal domain

  7. NM_001318714.2 → NP_001305643.1  kinesin-like protein KIFC3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
    Source sequence(s)
    AK296995, BC034234, BC041132, BC047051, DC402000
    Consensus CDS
    CCDS45494.1
    UniProtKB/TrEMBL
    B7Z8X8
    Related
    ENSP00000456239.1, ENST00000562903.5
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  8. NM_001318715.2 → NP_001305644.1  kinesin-like protein KIFC3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 4. It encodes isoform 3, which is shorter than isoform 4. Variants 3, 8 and 9 encode the same isoform (3).
    Source sequence(s)
    AC092118, AK291737, BC041132, BC047051
    Consensus CDS
    CCDS45494.1
    UniProtKB/TrEMBL
    B7Z8X8
    Related
    ENSP00000454659.1, ENST00000465878.6
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  9. NM_005550.4 → NP_005541.3  kinesin-like protein KIFC3 isoform 1

    See identical proteins and their annotated locations for NP_005541.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, uses a downstream start codon and lacks an exon in the 3' coding region, compared to variant 4. It encodes isoform 1, which is shorter and has distinct N- and C-termini, compared to isoform 4.
    Source sequence(s)
    AC092118, BC001211
    Consensus CDS
    CCDS10789.2
    UniProtKB/Swiss-Prot
    A8K6S2, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6, Q9BVG8
    UniProtKB/TrEMBL
    B7Z808
    Related
    ENSP00000368976.4, ENST00000379655.8
    Conserved Domains (3) summary
    COG1196
    Location:172 → 444
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:443 → 770
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam08961
    Location:131 → 164
    NRBF2; Nuclear receptor-binding factor 2, autophagy regulator

RNA

  1. NR_134678.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains multiple differences, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK295926, AK296995, BC041132, BC047051, DC402000
    Related
    ENST00000564136.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    57758217..57862858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434085.1 → XP_047290041.1  kinesin-like protein KIFC3 isoform X13

  2. XM_011523075.2 → XP_011521377.1  kinesin-like protein KIFC3 isoform X8

    UniProtKB/TrEMBL
    B7Z808
    Conserved Domains (3) summary
    cd01366
    Location:492 → 819
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:500 → 817
    Kinesin; Kinesin motor domain
    cl12013
    Location:226 → 413
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_011523076.2 → XP_011521378.1  kinesin-like protein KIFC3 isoform X9

    UniProtKB/TrEMBL
    B7Z808
    Conserved Domains (3) summary
    cd01366
    Location:492 → 819
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:500 → 817
    Kinesin; Kinesin motor domain
    cl12013
    Location:226 → 413
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_005255937.2 → XP_005255994.1  kinesin-like protein KIFC3 isoform X2

    Conserved Domains (3) summary
    cd01366
    Location:606 → 933
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:614 → 931
    Kinesin; Kinesin motor domain
    cl12013
    Location:340 → 527
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_017023221.2 → XP_016878710.1  kinesin-like protein KIFC3 isoform X3

  6. XM_006721188.2 → XP_006721251.1  kinesin-like protein KIFC3 isoform X1

    Conserved Domains (3) summary
    cd01366
    Location:632 → 959
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:640 → 957
    Kinesin; Kinesin motor domain
    cl12013
    Location:366 → 553
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. XM_047434084.1 → XP_047290040.1  kinesin-like protein KIFC3 isoform X12

    UniProtKB/Swiss-Prot
    A8K6S2, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6, Q9BVG8

  8. XM_047434080.1 → XP_047290036.1  kinesin-like protein KIFC3 isoform X5

  9. XM_011523077.2 → XP_011521379.1  kinesin-like protein KIFC3 isoform X10

    See identical proteins and their annotated locations for XP_011521379.1

    UniProtKB/TrEMBL
    B7Z808
    Conserved Domains (3) summary
    cd01366
    Location:471 → 798
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    pfam00225
    Location:479 → 796
    Kinesin; Kinesin motor domain
    cl12013
    Location:205 → 392
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  10. XM_047434083.1 → XP_047290039.1  kinesin-like protein KIFC3 isoform X11

  11. XM_011523078.2 → XP_011521380.1  kinesin-like protein KIFC3 isoform X16

    See identical proteins and their annotated locations for XP_011521380.1

    UniProtKB/TrEMBL
    B7Z8X8
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  12. XM_047434086.1 → XP_047290042.1  kinesin-like protein KIFC3 isoform X14

  13. XM_047434079.1 → XP_047290035.1  kinesin-like protein KIFC3 isoform X5

  14. XM_047434078.1 → XP_047290034.1  kinesin-like protein KIFC3 isoform X4

  15. XM_047434081.1 → XP_047290037.1  kinesin-like protein KIFC3 isoform X6

  16. XM_047434088.1 → XP_047290044.1  kinesin-like protein KIFC3 isoform X16

  17. XM_047434087.1 → XP_047290043.1  kinesin-like protein KIFC3 isoform X16

  18. XM_017023224.2 → XP_016878713.1  kinesin-like protein KIFC3 isoform X7

    UniProtKB/TrEMBL
    B7Z5U4

  19. XM_047434082.1 → XP_047290038.1  kinesin-like protein KIFC3 isoform X7

  20. XM_047434092.1 → XP_047290048.1  kinesin-like protein KIFC3 isoform X16

  21. XM_047434091.1 → XP_047290047.1  kinesin-like protein KIFC3 isoform X16

  22. XM_024450267.2 → XP_024306035.1  kinesin-like protein KIFC3 isoform X16

    UniProtKB/TrEMBL
    B7Z8X8
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  23. XM_024450266.2 → XP_024306034.1  kinesin-like protein KIFC3 isoform X16

    UniProtKB/TrEMBL
    B7Z8X8
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  24. XM_047434093.1 → XP_047290049.1  kinesin-like protein KIFC3 isoform X16

  25. XM_011523079.2 → XP_011521381.1  kinesin-like protein KIFC3 isoform X16

    See identical proteins and their annotated locations for XP_011521381.1

    UniProtKB/TrEMBL
    B7Z8X8
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  26. XM_047434089.1 → XP_047290045.1  kinesin-like protein KIFC3 isoform X16

  27. XM_047434090.1 → XP_047290046.1  kinesin-like protein KIFC3 isoform X16

  28. XM_024450268.2 → XP_024306036.1  kinesin-like protein KIFC3 isoform X16

    UniProtKB/TrEMBL
    B7Z8X8
    Conserved Domains (2) summary
    TIGR02168
    Location:3 → 301
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01366
    Location:304 → 631
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  29. XM_017023225.2 → XP_016878714.2  kinesin-like protein KIFC3 isoform X15

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63553374..63658232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380295.1 → XP_054236270.1  kinesin-like protein KIFC3 isoform X13

  2. XM_054380289.1 → XP_054236264.1  kinesin-like protein KIFC3 isoform X8

  3. XM_054380290.1 → XP_054236265.1  kinesin-like protein KIFC3 isoform X9

  4. XM_054380282.1 → XP_054236257.1  kinesin-like protein KIFC3 isoform X2

  5. XM_054380283.1 → XP_054236258.1  kinesin-like protein KIFC3 isoform X3

  6. XM_054380281.1 → XP_054236256.1  kinesin-like protein KIFC3 isoform X1

  7. XM_054380286.1 → XP_054236261.1  kinesin-like protein KIFC3 isoform X5

  8. XM_054380294.1 → XP_054236269.1  kinesin-like protein KIFC3 isoform X12

    UniProtKB/Swiss-Prot
    A8K6S2, B7Z484, O75299, Q49A29, Q49AQ0, Q59G19, Q8IUT3, Q96HW6, Q9BVG8

  9. XM_054380291.1 → XP_054236266.1  kinesin-like protein KIFC3 isoform X10

  10. XM_054380292.1 → XP_054236267.1  kinesin-like protein KIFC3 isoform X11

  11. XM_054380299.1 → XP_054236274.1  kinesin-like protein KIFC3 isoform X16

  12. XM_054380296.1 → XP_054236271.1  kinesin-like protein KIFC3 isoform X14

  13. XM_054380285.1 → XP_054236260.1  kinesin-like protein KIFC3 isoform X5

  14. XM_054380284.1 → XP_054236259.1  kinesin-like protein KIFC3 isoform X4

  15. XM_054380287.1 → XP_054236262.1  kinesin-like protein KIFC3 isoform X6

  16. XM_054380298.1 → XP_054236273.1  kinesin-like protein KIFC3 isoform X16

  17. XM_054380293.1 → XP_054236268.1  kinesin-like protein KIFC3 isoform X7

  18. XM_054380288.1 → XP_054236263.1  kinesin-like protein KIFC3 isoform X7

  19. XM_054380303.1 → XP_054236278.1  kinesin-like protein KIFC3 isoform X16

  20. XM_054380302.1 → XP_054236277.1  kinesin-like protein KIFC3 isoform X16

  21. XM_054380308.1 → XP_054236283.1  kinesin-like protein KIFC3 isoform X16

  22. XM_054380306.1 → XP_054236281.1  kinesin-like protein KIFC3 isoform X16

  23. XM_054380305.1 → XP_054236280.1  kinesin-like protein KIFC3 isoform X16

  24. XM_054380304.1 → XP_054236279.1  kinesin-like protein KIFC3 isoform X16

  25. XM_054380301.1 → XP_054236276.1  kinesin-like protein KIFC3 isoform X16

  26. XM_054380300.1 → XP_054236275.1  kinesin-like protein KIFC3 isoform X16

  27. XM_054380307.1 → XP_054236282.1  kinesin-like protein KIFC3 isoform X16

  28. XM_054380297.1 → XP_054236272.1  kinesin-like protein KIFC3 isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVG8.4 GenPept UniProtKB/Swiss-Prot:Q9BVG8

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