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Serf2 small EDRK-rich factor 2 [ Mus musculus (house mouse) ]

Gene ID: 378702, updated on 5-Mar-2024

Summary

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Official Symbol
Serf2provided by MGI
Official Full Name
small EDRK-rich factor 2provided by MGI
Primary source
MGI:MGI:1337041
See related
Ensembl:ENSMUSG00000074884 AllianceGenome:MGI:1337041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msmac1l; m4F5rel
Summary
Predicted to be involved in protein destabilization. Is expressed in several structures, including brain; cardiovascular system; endocrine gland; genitourinary system; and oral epithelium. Orthologous to human SERF2 (small EDRK-rich factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 128.1), large intestine adult (RPKM 95.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Serf2 in Genome Data Viewer
Location:
2 E5; 2 60.39 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121279679..121283901)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121449198..121453420)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene elongation factor RNA polymerase II-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E3398 Neighboring gene serine incorporator 4 Neighboring gene huntingtin interacting protein K Neighboring gene microfibrillar-associated protein 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits. Cleverley K, et al. Mamm Genome, 2021 Apr. PMID 33713180, Free PMC Article
  2. Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Stroo E, et al. Life Sci Alliance, 2023 Jul. PMID 37130781, Free PMC Article
  3. Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics. Scharf JM, et al. Nat Genet, 1998 Sep. PMID 9731538
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
    Title: Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
  2. A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.
    Title: A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
small EDRK-rich factor 2
Names
4F5rel (4F5 related)
protein 4F5-related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290837.1 → NP_001277766.1  small EDRK-rich factor 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK132746, BP768998, BY070249, CJ073462
    Consensus CDS
    CCDS71126.1
    UniProtKB/TrEMBL
    A2ARQ4
    Related
    ENSMUSP00000097074.5, ENSMUST00000099475.12
    Conserved Domains (1) summary
    pfam04419
    Location:1 → 37
    4F5; 4F5 protein family

  2. NM_011354.3 → NP_035484.1  small EDRK-rich factor 2 isoform b

    See identical proteins and their annotated locations for NP_035484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK132746, BP768998, CJ073462
    Consensus CDS
    CCDS16645.1
    UniProtKB/Swiss-Prot
    A2ARQ3, P84102
    UniProtKB/TrEMBL
    Q58DZ4
    Related
    ENSMUSP00000123181.2, ENSMUST00000139253.8
    Conserved Domains (1) summary
    pfam04419
    Location:1 → 37
    4F5; 4F5 protein family

RNA

  1. NR_110986.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA423654, AK132746, BP768998, CJ073462

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121279679..121283901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84102.1 GenPept UniProtKB/Swiss-Prot:P84102

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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