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KCNK2 potassium two pore domain channel subfamily K member 2 [ Homo sapiens (human) ]

Gene ID: 3776, updated on 5-Mar-2024

Summary

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Official Symbol
KCNK2provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 2provided by HGNC
Primary source
HGNC:HGNC:6277
See related
Ensembl:ENSG00000082482 MIM:603219; AllianceGenome:HGNC:6277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
Summary
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
1q41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (215005542..215237090)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (214245543..214477417)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (215178885..215410433)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 24 Neighboring gene uncharacterized LOC124904510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2534 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:215228700-215229418 Neighboring gene uncharacterized LOC124904511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:215256438-215256960 Neighboring gene NANOG hESC enhancer GRCh37_chr1:215325097-215325634 Neighboring gene voltage dependent anion channel 1 pseudogene 10 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:215588487-215589150 Neighboring gene uncharacterized LOC124904598

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells. Kondo R, et al. J Pharmacol Sci, 2022 Mar. PMID 35177207
  2. Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors. Mukherjee S, et al. Pflugers Arch, 2021 Feb. PMID 33025137
  3. A regulatory domain in the K(2P)2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes. Arazi E, et al. Mol Cell Neurosci, 2020 Jun. PMID 32320829
  4. Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current. Canella R, et al. J Cell Physiol, 2019 Aug. PMID 30805940
  5. Triple arginine residues in the proximal C-terminus of TREK K(+) channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate. Woo J, et al. Am J Physiol Cell Physiol, 2019 Mar 1. PMID 30576235

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
    Title: Prolonged stretching of rat uteri causes hypoxia and inhibits contractility via potassium channel TREK1.
  2. miR-132-3p promotes heat stimulation-induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2.
    Title: miR-132-3p promotes heat stimulation-induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2.
  3. High glucose induced HIF-1alpha/TREK1 expression and myometrium relaxation during pregnancy.
    Title: High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy.
  4. Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury.
    Title: Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A-induced lung injury.
  5. Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells.
    Title: Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells.
  6. Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.
    Title: Intracellular activation of full-length human TREK-1 channel by hypoxia, high lactate, and low pH denotes polymodal integration by ischemic factors.
  7. Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
    Title: Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
  8. A regulatory domain in the K2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes.
    Title: A regulatory domain in the K(2P)2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes.
  9. Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia.
    Title: Astrocytic AEG-1 regulates expression of TREK-1 under acute hypoxia.
  10. The activity of TREK-1 has a key role for the correct functioning of the alveolar epithelium.
    Title: Involvement of the TREK-1 channel in human alveolar cell membrane potential and its regulation by inhibitors of the chloride current.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126742, MGC126744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium ion leak channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac ventricle development IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in cochlea development IEA
Inferred from Electronic Annotation
more info
  
involved_in memory IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
  
located_in calyx of Held IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
potassium channel subfamily K member 2
Names
K2P2.1 potassium channel
TREK-1 K(+) channel subunit
TWIK-related potassium channel 1
outward rectifying potassium channel protein TREK-1
potassium channel, two pore domain subfamily K, member 2
potassium inwardly-rectifying channel, subfamily K, member 2
tandem-pore-domain potassium channel TREK-1
two pore domain potassium channel TREK-1
two pore potassium channel TPKC1
two-pore potassium channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017424.3 → NP_001017424.1  potassium channel subfamily K member 2 isoform a

    See identical proteins and their annotated locations for NP_001017424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC092804, AK123409, AL583830, AU280191, BC069462, CD625291, CD625297, DA475072
    Consensus CDS
    CCDS41466.1
    UniProtKB/TrEMBL
    U3N834
    Related
    ENSP00000375765.2, ENST00000391895.6
    Conserved Domains (1) summary
    pfam07885
    Location:137 → 192
    Ion_trans_2; Ion channel

  2. NM_001017425.3 → NP_001017425.2  potassium channel subfamily K member 2 isoform c

    See identical proteins and their annotated locations for NP_001017425.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and beginning of the coding region compared to variant 1. The resulting isoform (c) is slightly shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC092804, AC099675, AK123409, BC069462, DR001358, EF165334
    Consensus CDS
    CCDS41467.1
    UniProtKB/Swiss-Prot
    A1Z1V3, A8K618, B2RCS4, B7ZL56, D3DTA5, O95069, Q5DP47, Q5DP48, Q9NRT2, Q9UNE3
    Related
    ENSP00000394033.2, ENST00000444842.7
    Conserved Domains (1) summary
    pfam07885
    Location:142 → 196
    Ion_trans_2; Ion channel

  3. NM_014217.4 → NP_055032.1  potassium channel subfamily K member 2 isoform b

    See identical proteins and their annotated locations for NP_055032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and beginning of the open reading frame compared to variant 1. The resulting isoform (b) is slightly shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC092804, AC099675, AK123409, BC069462, BC101693, DR001358
    Consensus CDS
    CCDS31024.1
    UniProtKB/TrEMBL
    U3N6F0
    Related
    ENSP00000375764.2, ENST00000391894.6
    Conserved Domains (1) summary
    pfam07885
    Location:127 → 181
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    215005542..215237090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001249.2 → XP_016856738.1  potassium channel subfamily K member 2 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:127 → 182
    Ion_trans_2; Ion channel

  2. XM_011509524.3 → XP_011507826.1  potassium channel subfamily K member 2 isoform X2

    See identical proteins and their annotated locations for XP_011507826.1

    Conserved Domains (1) summary
    pfam07885
    Location:86 → 140
    Ion_trans_2; Ion channel

  3. XM_011509522.3 → XP_011507824.1  potassium channel subfamily K member 2 isoform X2

    See identical proteins and their annotated locations for XP_011507824.1

    Conserved Domains (1) summary
    pfam07885
    Location:86 → 140
    Ion_trans_2; Ion channel

  4. XM_047419881.1 → XP_047275837.1  potassium channel subfamily K member 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    214245543..214477417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336482.1 → XP_054192457.1  potassium channel subfamily K member 2 isoform X1

  2. XM_054336483.1 → XP_054192458.1  potassium channel subfamily K member 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95069.2 GenPept UniProtKB/Swiss-Prot:O95069

Gene LinkOut

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