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ZC3H6 zinc finger CCCH-type containing 6 [ Homo sapiens (human) ]

Gene ID: 376940, updated on 5-Mar-2024

Summary

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Official Symbol
ZC3H6provided by HGNC
Official Full Name
zinc finger CCCH-type containing 6provided by HGNC
Primary source
HGNC:HGNC:24762
See related
Ensembl:ENSG00000188177 AllianceGenome:HGNC:24762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3HDC6
Summary
Predicted to enable RNA binding activity and metal ion binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 3.2), thyroid (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ZC3H6 in Genome Data Viewer
Location:
2q14.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (112275597..112340059)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (112702473..112766918)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113033174..113097636)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fibulin 7 Neighboring gene zinc finger CCCH-type containing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11870 Neighboring gene CRISPRi-validated cis-regulatory element chr2.4107 Neighboring gene uncharacterized LOC124906182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:113032876-113033448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11871 Neighboring gene MPRA-validated peak3818 silencer Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 6 Neighboring gene uncharacterized LOC124906067 Neighboring gene axin 2 pseudogene Neighboring gene RANBP2 like and GRIP domain containing 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, et al. Nat Commun, 2021 Feb 26. PMID 33637726, Free PMC Article
  2. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Andresen CA, et al. J Biol Chem, 2014 Jan 24. PMID 24337577, Free PMC Article
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  4. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Rosenbluh J, et al. Cell Syst, 2016 Sep 28. PMID 27684187, Free PMC Article
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16526, FLJ41410, FLJ45877, KIAA2035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 6
Names
zinc finger CCCH-type domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198581.3 → NP_940983.2  zinc finger CCCH domain-containing protein 6

    See identical proteins and their annotated locations for NP_940983.2

    Status: VALIDATED

    Source sequence(s)
    AC115115, AK131416, BM683817, DA334613
    Consensus CDS
    CCDS46393.1
    UniProtKB/Swiss-Prot
    A9JR71, P61129, Q6ZW96
    Related
    ENSP00000386764.1, ENST00000409871.6
    Conserved Domains (1) summary
    smart00356
    Location:303 → 327
    ZnF_C3H1; zinc finger

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    112275597..112340059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712519.4 → XP_006712582.1  zinc finger CCCH domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    smart00356
    Location:303 → 327
    ZnF_C3H1; zinc finger

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    112702473..112766918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341940.1 → XP_054197915.1  zinc finger CCCH domain-containing protein 6 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61129.2 GenPept UniProtKB/Swiss-Prot:P61129

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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