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PTAR1 protein prenyltransferase alpha subunit repeat containing 1 [ Homo sapiens (human) ]

Gene ID: 375743, updated on 5-Mar-2024

Summary

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Official Symbol
PTAR1provided by HGNC
Official Full Name
protein prenyltransferase alpha subunit repeat containing 1provided by HGNC
Primary source
HGNC:HGNC:30449
See related
Ensembl:ENSG00000188647 AllianceGenome:HGNC:30449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein prenyltransferase activity. Predicted to be involved in protein prenylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 7.3), bone marrow (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9q21.12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (69709525..69760011, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (81876142..81926623, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (72324441..72374927, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902177 Neighboring gene Sharpr-MPRA regulatory region 1664 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:72081305-72082504 Neighboring gene amyloid beta precursor protein binding family A member 1 Neighboring gene uncharacterized LOC124902178 Neighboring gene 9q21.12 proximal LINE-mediated recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:72120629-72121248 Neighboring gene 9q21.12 distal LINE-mediated recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19936 Neighboring gene uncharacterized LOC105376076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:72375949-72376804 Neighboring gene Sharpr-MPRA regulatory region 8756 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:72377659-72378514 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:72378515-72379369 Neighboring gene Sharpr-MPRA regulatory region 12610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19937 Neighboring gene CFAP95 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase. Kuchay S, et al. Nat Struct Mol Biol, 2019 Jul. PMID 31209342, Free PMC Article
  2. A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus. Shirakawa R, et al. EMBO J, 2020 Apr 15. PMID 32128853, Free PMC Article
  3. Gene essentiality and synthetic lethality in haploid human cells. Blomen VA, et al. Science, 2015 Nov 27. PMID 26472760
  4. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. Adhikari H, et al. Nat Commun, 2018 Sep 7. PMID 30194290, Free PMC Article
  5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ45604

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein prenylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein prenyltransferase alpha subunit repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099666.2 → NP_001093136.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001093136.1

    Status: VALIDATED

    Source sequence(s)
    AI937926, AL162412, BC053622, BM785278
    Consensus CDS
    CCDS47978.1
    UniProtKB/Swiss-Prot
    Q5T7V5, Q5T7V6, Q7Z6K3
    Related
    ENSP00000344299.4, ENST00000340434.5
    Conserved Domains (1) summary
    pfam01239
    Location:180 → 207
    PPTA; Protein prenyltransferase alpha subunit repeat

  2. NM_001366935.1 → NP_001353864.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL162412
    Consensus CDS
    CCDS94417.1
    UniProtKB/TrEMBL
    X6R9N0
    Related
    ENSP00000366405.5, ENST00000377200.9
    Conserved Domains (1) summary
    pfam01239
    Location:101 → 128
    PPTA; Protein prenyltransferase alpha subunit repeat

  3. NM_001366936.1 → NP_001353865.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL162412
    Conserved Domains (1) summary
    cl27590
    Location:82 → 208
    PPTA; Protein prenyltransferase alpha subunit repeat

  4. NM_001366937.1 → NP_001353866.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL162412
    Conserved Domains (1) summary
    cl27590
    Location:88 → 208
    PPTA; Protein prenyltransferase alpha subunit repeat

  5. NM_001366938.1 → NP_001353867.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL162412
    Conserved Domains (1) summary
    pfam01239
    Location:101 → 128
    PPTA; Protein prenyltransferase alpha subunit repeat

  6. NM_001366939.1 → NP_001353868.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL162412
    Conserved Domains (1) summary
    cl27590
    Location:88 → 208
    PPTA; Protein prenyltransferase alpha subunit repeat

  7. NM_001366940.1 → NP_001353869.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL162412
    Conserved Domains (1) summary
    PLN02789
    Location:88 → 208
    PLN02789; farnesyltranstransferase

RNA

  1. NR_159515.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL162412

  2. NR_159516.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL162412

  3. NR_159517.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL162412

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    69709525..69760011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423355.1 → XP_047279311.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X5

  2. XM_047423353.1 → XP_047279309.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X2

  3. XM_011518639.2 → XP_011516941.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam01239
    Location:142 → 169
    PPTA; Protein prenyltransferase alpha subunit repeat

  4. XM_005251980.6 → XP_005252037.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X4

    Conserved Domains (1) summary
    PLN02789
    Location:88 → 208
    PLN02789; farnesyltranstransferase

  5. XM_047423354.1 → XP_047279310.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    81876142..81926623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362930.1 → XP_054218905.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X5

  2. XM_054362927.1 → XP_054218902.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X2

  3. XM_054362926.1 → XP_054218901.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X1

  4. XM_054362929.1 → XP_054218904.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X4

  5. XM_054362928.1 → XP_054218903.1  protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z6K3.2 GenPept UniProtKB/Swiss-Prot:Q7Z6K3

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