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C5orf34 chromosome 5 open reading frame 34 [ Homo sapiens (human) ]

Gene ID: 375444, updated on 5-Mar-2024

Summary

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Official Symbol
C5orf34provided by HGNC
Official Full Name
chromosome 5 open reading frame 34provided by HGNC
Primary source
HGNC:HGNC:24738
See related
Ensembl:ENSG00000172244 AllianceGenome:HGNC:24738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 1.9), lymph node (RPKM 1.1) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
5p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43486709..43515148, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43739532..43767935, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43486811..43515250, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15994 Neighboring gene Sharpr-MPRA regulatory region 10963 Neighboring gene transmembrane protein 267 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43483998-43484841 Neighboring gene C5orf34 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85282 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 Neighboring gene uncharacterized LOC124900190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43521939-43522548 Neighboring gene poly(A) binding protein interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15995 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:43580594-43581340 Neighboring gene NNT antisense RNA 1 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Up-regulation of C5orf34 promotes lung adenocarcinoma migration and is correlated with worse prognosis. He D, et al. Gene, 2019 May 15. PMID 30771479
  2. Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, et al. Mol Cell, 2021 Jun 17. PMID 33957083
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  4. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ32363, MGC46448

General protein information

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Preferred Names
uncharacterized protein C5orf34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198566.4 → NP_940968.1  uncharacterized protein C5orf34

    See identical proteins and their annotated locations for NP_940968.1

    Status: VALIDATED

    Source sequence(s)
    AK056925, BC036867, DB453004
    Consensus CDS
    CCDS3946.1
    UniProtKB/Swiss-Prot
    Q96MH7
    Related
    ENSP00000303490.2, ENST00000306862.7
    Conserved Domains (2) summary
    pfam15016
    Location:451 → 538
    DUF4520; Domain of unknown function (DUF4520)
    pfam15025
    Location:7 → 151
    DUF4524; Domain of unknown function (DUF4524)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    43486709..43515148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009446.2 → XP_016864935.1  uncharacterized protein C5orf34 isoform X2

  2. XM_017009445.2 → XP_016864934.1  uncharacterized protein C5orf34 isoform X2

  3. XM_011514038.4 → XP_011512340.1  uncharacterized protein C5orf34 isoform X1

    Conserved Domains (2) summary
    pfam15016
    Location:451 → 538
    DUF4520; Domain of unknown function (DUF4520)
    pfam15025
    Location:7 → 151
    DUF4524; Domain of unknown function (DUF4524)

  4. XM_047417156.1 → XP_047273112.1  uncharacterized protein C5orf34 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    43739532..43767935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352534.1 → XP_054208509.1  uncharacterized protein C5orf34 isoform X1

  2. XM_054352535.1 → XP_054208510.1  uncharacterized protein C5orf34 isoform X2

  3. XM_054352536.1 → XP_054208511.1  uncharacterized protein C5orf34 isoform X2

  4. XM_054352533.1 → XP_054208508.1  uncharacterized protein C5orf34 isoform X4

    UniProtKB/Swiss-Prot
    Q96MH7

  5. XM_054352537.1 → XP_054208512.1  uncharacterized protein C5orf34 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96MH7.3 GenPept UniProtKB/Swiss-Prot:Q96MH7

Gene LinkOut

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