Alp2 Alkaline phosphatase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Alp2provided by FlyBase
Official Full Name: Alkaline phosphatase 2provided by FlyBase
Primary source: FLYBASE:FBgn0283480
Locus tag: Dmel_CG3290
See related: AllianceGenome:FB:FBgn0283480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aph-2; CG3290; Dmel\CG3290
Summary: Enables alkaline phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPL (alkaline phosphatase, biomineralization associated); ALPG (alkaline phosphatase, germ cell); and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22206005..22207987, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18093510..18095492, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkaline phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info

NP_611654.1

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The following sections contain reference sequences that belong to a specific genome build. Explain