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ZSWIM9 zinc finger SWIM-type containing 9 [ Homo sapiens (human) ]

Gene ID: 374920, updated on 5-Mar-2024

Summary

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Official Symbol
ZSWIM9provided by HGNC
Official Full Name
zinc finger SWIM-type containing 9provided by HGNC
Primary source
HGNC:HGNC:34495
See related
Ensembl:ENSG00000185453 AllianceGenome:HGNC:34495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf68
Summary
Predicted to act upstream of or within hematopoietic progenitor cell differentiation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 3.0), fat (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48170680..48197620)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51164635..51191690)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48673937..48700877)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48564610-48565203 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48565204-48565796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48565797-48566389 Neighboring gene phospholipase A2 group IVC Neighboring gene PLA2G4C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10871 Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:48673083-48673742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14872 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48691653-48691885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48699771-48700283 Neighboring gene caspase recruitment domain family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14873 Neighboring gene uncharacterized LOC124904734 Neighboring gene vomeronasal 1 receptor 97 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes. Hassan IU, et al. Zool Res, 2023 May 18. PMID 37161653, Free PMC Article
  2. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
  3. A comprehensive resource of interacting protein regions for refining human transcription factor networks. Miyamoto-Sato E, et al. PLoS One, 2010 Feb 24. PMID 20195357, Free PMC Article
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Hosgood HD 3rd, et al. Occup Environ Med, 2009 Dec. PMID 19773279, Free PMC Article
  5. A High-Density Map for Navigating the Human Polycomb Complexome. Hauri S, et al. Cell Rep, 2016 Oct 4. PMID 27705803

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC50339

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein ZSWIM9
Names
uncharacterized protein C19orf68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199341.4 → NP_955373.3  uncharacterized protein ZSWIM9

    See identical proteins and their annotated locations for NP_955373.3

    Status: VALIDATED

    Source sequence(s)
    AC011466, BC043386
    Consensus CDS
    CCDS74411.1
    UniProtKB/Swiss-Prot
    Q86XI8
    Related
    ENSP00000480314.1, ENST00000614654.2
    Conserved Domains (1) summary
    pfam03101
    Location:97 → 128
    FAR1; FAR1 DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48170680..48197620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259449.4 → XP_005259506.1  uncharacterized protein ZSWIM9 isoform X2

    Conserved Domains (1) summary
    pfam03101
    Location:110 → 141
    FAR1; FAR1 DNA-binding domain

  2. XM_006723204.4 → XP_006723267.1  uncharacterized protein ZSWIM9 isoform X1

    Conserved Domains (1) summary
    pfam03101
    Location:124 → 155
    FAR1; FAR1 DNA-binding domain

  3. XM_006723205.3 → XP_006723268.1  uncharacterized protein ZSWIM9 isoform X3

    See identical proteins and their annotated locations for XP_006723268.1

    Conserved Domains (1) summary
    pfam03101
    Location:97 → 128
    FAR1; FAR1 DNA-binding domain

  4. XM_011526936.3 → XP_011525238.1  uncharacterized protein ZSWIM9 isoform X4

    Conserved Domains (1) summary
    pfam03101
    Location:9 → 56
    FAR1; FAR1 DNA-binding domain

  5. XM_047438788.1 → XP_047294744.1  uncharacterized protein ZSWIM9 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51164635..51191690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320933.1 → XP_054176908.1  uncharacterized protein ZSWIM9 isoform X3

  2. XM_054320931.1 → XP_054176906.1  uncharacterized protein ZSWIM9 isoform X2

  3. XM_054320930.1 → XP_054176905.1  uncharacterized protein ZSWIM9 isoform X1

  4. XM_054320932.1 → XP_054176907.1  uncharacterized protein ZSWIM9 isoform X4

  5. XM_054320934.1 → XP_054176909.1  uncharacterized protein ZSWIM9 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86XI8.2 GenPept UniProtKB/Swiss-Prot:Q86XI8

Gene LinkOut

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