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ZNF829 zinc finger protein 829 [ Homo sapiens (human) ]

Gene ID: 374899, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF829provided by HGNC
Official Full Name
zinc finger protein 829provided by HGNC
Primary source
HGNC:HGNC:34032
See related
Ensembl:ENSG00000185869 AllianceGenome:HGNC:34032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.5), ovary (RPKM 1.1) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36888124..36916291, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39563809..39592026, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37379026..37407193, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC728485 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:37282721-37283221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14534 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene zinc finger protein 790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14535 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37368334-37369533 Neighboring gene zinc finger protein 345 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37382329-37383528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene zinc finger protein 568 Neighboring gene zinc finger protein 420 Neighboring gene uncharacterized LOC105372390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10553

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  3. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
  4. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307
  5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ27459, MGC129866, MGC129867, DKFZp779O175, DKFZp686K21248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 829

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037232.4 → NP_001032309.2  zinc finger protein 829 isoform 2

    See identical proteins and their annotated locations for NP_001032309.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008733, BC107132, BX538288, DB031896
    Consensus CDS
    CCDS42557.1
    UniProtKB/Swiss-Prot
    A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
    Related
    ENSP00000429266.1, ENST00000391711.8
    Conserved Domains (3) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box
    COG5048
    Location:158 → 344
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001171979.2 → NP_001165450.1  zinc finger protein 829 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AC008733, BX538288
    Consensus CDS
    CCDS59380.1
    UniProtKB/Swiss-Prot
    Q3KNS6
    Related
    ENSP00000428679.2, ENST00000520965.5
    Conserved Domains (6) summary
    smart00349
    Location:116 → 176
    KRAB; krueppel associated box
    COG5048
    Location:149 → 425
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:295 → 315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:238 → 259
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:116 → 155
    KRAB; KRAB box
    pfam13465
    Location:335 → 359
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36888124..36916291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526933.3 → XP_011525235.1  zinc finger protein 829 isoform X1

    See identical proteins and their annotated locations for XP_011525235.1

    UniProtKB/Swiss-Prot
    A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
    Conserved Domains (3) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box
    COG5048
    Location:158 → 344
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_005258876.4 → XP_005258933.1  zinc finger protein 829 isoform X1

    See identical proteins and their annotated locations for XP_005258933.1

    UniProtKB/Swiss-Prot
    A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
    Conserved Domains (3) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box
    COG5048
    Location:158 → 344
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:214 → 234
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39563809..39592026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320927.1 → XP_054176902.1  zinc finger protein 829 isoform X1

    UniProtKB/Swiss-Prot
    A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657

  2. XM_054320926.1 → XP_054176901.1  zinc finger protein 829 isoform X1

    UniProtKB/Swiss-Prot
    A0A075B6T0, Q3KNS6, Q3KNS7, Q6ZNN0, Q7Z657
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KNS6.1 GenPept UniProtKB/Swiss-Prot:Q3KNS6

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