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TMEM205 transmembrane protein 205 [ Homo sapiens (human) ]

Gene ID: 374882, updated on 10-Dec-2024

Summary

Official Symbol
TMEM205provided by HGNC
Official Full Name
transmembrane protein 205provided by HGNC
Primary source
HGNC:HGNC:29631
See related
Ensembl:ENSG00000105518 MIM:613771; AllianceGenome:HGNC:29631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ501
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in liver (RPKM 32.8), thyroid (RPKM 28.6) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM205 in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11342778..11346492, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11469756..11473392, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11453454..11456944, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene tetraspanin 16 Neighboring gene uncharacterized HSPC102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14008 Neighboring gene RAB3D, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11456465-11457295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11461146-11461646 Neighboring gene coiled-coil domain containing 159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11467020-11467961 Neighboring gene phospholipid phosphatase related 2

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC3205, MGC110858

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane  

General protein information

Preferred Names
transmembrane protein 205
Names
MBC3205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145416.2NP_001138888.1  transmembrane protein 205

    See identical proteins and their annotated locations for NP_001138888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC091472, BE889078
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000468733.1, ENST00000593256.6
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)
  2. NM_001321112.2NP_001308041.1  transmembrane protein 205

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC024575, BQ639667, CB994930
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000466495.1, ENST00000588560.5
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)
  3. NM_001321113.2NP_001308042.1  transmembrane protein 205

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC024575, BM352837, CB994930
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000466986.1, ENST00000586590.5
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)
  4. NM_001321114.2NP_001308043.1  transmembrane protein 205

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    BM451378, CB994930
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000465553.1, ENST00000589555.5
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)
  5. NM_033408.4NP_212133.1  transmembrane protein 205

    See identical proteins and their annotated locations for NP_212133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC008365, BE889078
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000398258.1, ENST00000447337.5
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)
  6. NM_198536.3NP_940938.1  transmembrane protein 205

    See identical proteins and their annotated locations for NP_940938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    BC064948, BC091472, BE889078
    Consensus CDS
    CCDS32909.1
    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000346954.4, ENST00000354882.10
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11342778..11346492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451501.2XP_024307269.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000465149.1, ENST00000587948.5
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)
  2. XM_024451500.2XP_024307268.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)
  3. XM_005259899.3XP_005259956.1  transmembrane protein 205 isoform X1

    See identical proteins and their annotated locations for XP_005259956.1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
    Related
    ENSP00000465483.1, ENST00000586956.5
    Conserved Domains (1) summary
    pfam13664
    Location:17114
    DUF4149; Domain of unknown function (DUF4149)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11469756..11473392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320915.1XP_054176890.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
  2. XM_054320914.1XP_054176889.1  transmembrane protein 205 isoform X1

    UniProtKB/Swiss-Prot
    Q6UW68
    UniProtKB/TrEMBL
    K7ELQ9
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