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WASH3P WASP family homolog 3, pseudogene [ Homo sapiens (human) ]

Gene ID: 374666, updated on 23-Nov-2023

Summary

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Official Symbol
WASH3Pprovided by HGNC
Official Full Name
WASP family homolog 3, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:24362
See related
AllianceGenome:HGNC:24362
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM39DP
Summary
Predicted to enable alpha-tubulin binding activity. Involved in several processes, including Arp2/3 complex-mediated actin nucleation; early endosome to late endosome transport; and protein targeting to lysosome. Located in endosome; filopodium; and lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 26.3), spleen (RPKM 26.3) and 25 other tissues See more
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Genomic context

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Location:
15q26.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101960813..101976605)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99730108..99745901)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (102501016..102516808)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 138 member E Neighboring gene microRNA 1302-10 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr15:102501427-102501928 Neighboring gene microRNA 6859-3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102514808-102515364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:102516478-102517033 Neighboring gene DEAD/H-box helicase 11 like 9 (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WASH and the Arp2/3 complex regulate endosome shape and trafficking. Duleh SN, et al. Cytoskeleton (Hoboken), 2010 Mar. PMID 20175130, Free PMC Article
  2. Characterization of the murine orthologue of a novel human subtelomeric multigene family. Gianfrancesco F, et al. Cytogenet Cell Genet, 2001. PMID 11701968
  3. Human subtelomeric WASH genes encode a new subclass of the WASP family. Linardopoulou EV, et al. PLoS Genet, 2007 Dec. PMID 18159949, Free PMC Article
  4. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. Ciccodicola A, et al. Hum Mol Genet, 2000 Feb 12. PMID 10655549
  5. A FAM21-containing WASH complex regulates retromer-dependent sorting. Gomez TS, et al. Dev Cell, 2009 Nov. PMID 19922874, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • WAS protein family homolog 3, pseudogene
  • family with sequence similarity 39, member D pseudogene

Clone Names

  • FLJ25222, FLJ57306, FLJ75027, FLJ77846, FLJ78059, MGC52000, MGC117230

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosomal transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to lysosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of WASH complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003659.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140725, AK056232, AK057951, AW604905, BQ722707, BQ935819, BQ937971, DA065132

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    101960813..101976605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160015.1 Reference GRCh38.p14 PATCHES

    Range
    66950..82742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    99730108..99745901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199163.2: Suppressed sequence

    Description
    NM_199163.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C4AMC7.2 GenPept UniProtKB/Swiss-Prot:C4AMC7

Gene LinkOut

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Chemical Information
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Research Materials
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