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KRT77 keratin 77 [ Homo sapiens (human) ]

Gene ID: 374454, updated on 7-Apr-2024

Summary

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Official Symbol
KRT77provided by HGNC
Official Full Name
keratin 77provided by HGNC
Primary source
HGNC:HGNC:20411
See related
Ensembl:ENSG00000189182 MIM:611158; AllianceGenome:HGNC:20411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K1B; KRT1B
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Expression
Restricted expression toward skin (RPKM 121.1) See more
Orthologs
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Genomic context

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See KRT77 in Genome Data Viewer
Location:
12q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52689626..52703524, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52654148..52668031, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53083410..53097308, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53068684-53069184 Neighboring gene keratin 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29208 Neighboring gene keratin 126, pseudogene Neighboring gene DEAD-box helicase 23 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain. Hinbest AJ, et al. Int J Mol Sci, 2020 Sep 10. PMID 32927888, Free PMC Article
  2. Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands. Langbein L, et al. J Invest Dermatol, 2005 Sep. PMID 16117782
  3. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. Hesse M, et al. J Cell Sci, 2001 Jul. PMID 11683385
  4. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. Rogers MA, et al. J Invest Dermatol, 2005 Mar. PMID 15737194
  5. RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers. Pang K, et al. Nat Commun, 2019 Dec 20. PMID 31862882, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain.
    Title: Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain.
  2. Epithelial keratin, K1b, is exclusively expressed in luminal duct cells of eccrine sweat glands.
    Title: Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC148087

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cornified envelope IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
keratin, type II cytoskeletal 1b
Names
CK-1B
K77
cytokeratin-1B
keratin 1B
keratin 77, type II
type-II keratin Kb39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012322.1 RefSeqGene

    Range
    4940..18838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175078.3 → NP_778253.2  keratin, type II cytoskeletal 1b

    See identical proteins and their annotated locations for NP_778253.2

    Status: REVIEWED

    Source sequence(s)
    AC055716, BC122558
    Consensus CDS
    CCDS8837.1
    UniProtKB/Swiss-Prot
    Q7RTS8, Q7Z794
    UniProtKB/TrEMBL
    Q0IIN1
    Related
    ENSP00000342710.3, ENST00000341809.8
    Conserved Domains (3) summary
    pfam00038
    Location:163 → 476
    Filament; Intermediate filament protein
    pfam16208
    Location:56 → 160
    Keratin_2_head; Keratin type II head
    cl23720
    Location:384 → 451
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    52689626..52703524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538288.3 → XP_011536590.1  keratin, type II cytoskeletal 1b isoform X1

    UniProtKB/TrEMBL
    Q147W7
    Conserved Domains (1) summary
    pfam00038
    Location:1 → 243
    Filament; Intermediate filament protein

  2. XM_011538289.3 → XP_011536591.1  keratin, type II cytoskeletal 1b isoform X2

    Conserved Domains (1) summary
    pfam16208
    Location:56 → 160
    Keratin_2_head; Keratin type II head

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    52654148..52668031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371976.1 → XP_054227951.1  keratin, type II cytoskeletal 1b isoform X1

  2. XM_054371977.1 → XP_054227952.1  keratin, type II cytoskeletal 1b isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z794.3 GenPept UniProtKB/Swiss-Prot:Q7Z794

Gene LinkOut

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