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GstE5 Glutathione S transferase E5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37110, updated on 27-Mar-2024

Summary

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Official Symbol
GstE5provided by FlyBase
Official Full Name
Glutathione S transferase E5provided by FlyBase
Primary source
FLYBASE:FBgn0063495
Locus tag
Dmel_CG17527
See related
AllianceGenome:FB:FBgn0063495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17527; Dmel\CG17527; DmGSTE5; gste5; gstE5; GSTE5
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
55C7-55C7; 2-85 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18404605..18405338)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14292110..14292843)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Glutathione S transferase E4 Neighboring gene Glutathione S transferase E6 Neighboring gene Glutathione S transferase E7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Behavioral and Transcriptional Response to Selection for Olfactory Behavior in Drosophila. Brown EB, et al. G3 (Bethesda), 2020 Apr 9. PMID 32024668, Free PMC Article
  2. Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. Zhao HW, et al. J Biol Chem, 2011 Feb 25. PMID 21148307, Free PMC Article
  3. Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness. Aw WC, et al. PLoS Genet, 2018 Nov. PMID 30399141, Free PMC Article
  4. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
  5. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S transferase E5
Names
CG17527-PA
GstE5-PA
NP_611327.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18404605..18405338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137483.3 → NP_611327.1  glutathione S transferase E5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611327.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB70, Q5BI69
    Related
    FBpp0085854
    Conserved Domains (3) summary
    cd03177
    Location:91 → 209
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:4 → 196
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:4 → 77
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZB70 A1ZB70
Q5BI69 Q5BI69

Gene LinkOut

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