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NaPi-T Na[+]-dependent inorganic phosphate cotransporter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36651, updated on 11-Apr-2024

Summary

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Official Symbol
NaPi-Tprovided by FlyBase
Official Full Name
Na[+]-dependent inorganic phosphate cotransporterprovided by FlyBase
Primary source
FLYBASE:FBgn0016684
Locus tag
Dmel_CG10207
See related
AllianceGenome:FB:FBgn0016684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10207; Dmel\CG10207; Dropo; MFS2; Na/Pi-cotransporter; NapiT
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in anion transport. Predicted to be integral component of membrane. Is expressed in several structures, including Malpighian tubule; embryonic/larval central nervous system; embryonic/larval digestive system; extended germ band embryo; and yolk nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
51C5-51C5; 2-72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14842720..14845874, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10730225..10733379, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45329 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules. Rose E, et al. Sci Rep, 2019 Jun 19. PMID 31217461, Free PMC Article
  2. A putative sodium-dependent inorganic phosphate co-transporter from Drosophila melanogaster. MacIver B, et al. Dev Genes Evol, 2000 Apr. PMID 11180823
  3. Embryonic expression patterns of Drosophila ACS family genes related to the human sialin gene. Laridon B, et al. Gene Expr Patterns, 2008 Apr. PMID 18255354
  4. Drosophila melanogaster: a simple genetic model of kidney structure, function and disease. Dow JAT, et al. Nat Rev Nephrol, 2022 Jul. PMID 35411063
  5. An abundant quiescent stem cell population in Drosophila Malpighian tubules protects principal cells from kidney stones. Wang C, et al. Elife, 2020 Mar 16. PMID 32175841, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules.
    Title: Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Na[+]-dependent inorganic phosphate cotransporter
Names
CG10207-PA
CG10207-PB
NaPi-T-PA
NaPi-T-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14842720..14845874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080377.3 → NP_525116.2  Na[+]-dependent inorganic phosphate cotransporter, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525116.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZR4, Q94886
    Related
    FBpp0086593
    Conserved Domains (2) summary
    cd06174
    Location:76 → 460
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1 → 474
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

  2. NM_001274052.2 → NP_001260981.1  Na[+]-dependent inorganic phosphate cotransporter, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260981.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZR4, Q94886
    Conserved Domains (2) summary
    cd06174
    Location:76 → 460
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:1 → 474
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JZR4 Q7JZR4
Q94886 Q94886

Gene LinkOut

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