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AttA Attacin-A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36636, updated on 4-Apr-2024

Summary

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Official Symbol
AttAprovided by FlyBase
Official Full Name
Attacin-Aprovided by FlyBase
Primary source
FLYBASE:FBgn0012042
Locus tag
Dmel_CG10146
See related
AllianceGenome:FB:FBgn0012042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AHA; anon-WO0140519.5; att; Att; ATT; att A; Att A; Att-A; attA; AttaA; attacin; Attacin A; AttacinA; BcDNA:LP05763; CG10146; Dmel\CG10146
Summary
Involved in defense response to other organism and response to hyperoxia. Located in extracellular space. Is expressed in embryonic/larval hemolymph. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
51C1-51C1; 2-72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14747362..14748215)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10634867..10635720)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene jet fuel Neighboring gene Drosocin Neighboring gene Attacin-B Neighboring gene Regulatory particle non-ATPase 6 Neighboring gene aveugle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Growing bacteria shed elicitors of Drosophila humoral immunity. Karlsson J, et al. J Innate Immun, 2012. PMID 21829001
  2. Molecular cloning, expression in Escherichia coli of Attacin A gene from Drosophila and detection of biological activity. Wang LN, et al. Mol Biol Rep, 2010 Jun. PMID 19711194
  3. Identification of early genes in the Drosophila immune response by PCR-based differential display: the Attacin A gene and the evolution of attacin-like proteins. Asling B, et al. Insect Biochem Mol Biol, 1995 Apr. PMID 7742836
  4. Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects. Woolley VC, et al. J Invertebr Pathol, 2020 Nov. PMID 33022282, Free PMC Article
  5. The effect of mating on immunity can be masked by experimental piercing in female Drosophila melanogaster. Wigby S, et al. J Insect Physiol, 2008 Feb. PMID 18068720, Free PMC Article

See all (433) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that in response to infection Drosophila egg expressed several immune genes including AttacinA (CG10146), CecropinA1 (CG1365) and CecropinB (CG1878).
    Title: Immune competence in insect eggs depends on the extraembryonic serosa.
  2. the Drosophila melanogaster attacin C Pro-domain has antibacterial properties
    Title: Primary structure and in vitro antibacterial properties of the Drosophila melanogaster attacin C Pro-domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in antibacterial humoral response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-negative bacterium NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to insect IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in humoral immune response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hyperoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Attacin-A
Names
AttA-PA
Attacin-A precursor
CG10146-PA
attacin
attacin A
attacinA
attackin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14747362..14748215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079021.5 → NP_523745.1  Attacin-A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523745.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P45884, Q9V750
    Related
    FBpp0086567
    Conserved Domains (2) summary
    pfam03768
    Location:34 → 99
    Attacin_N; Attacin, N-terminal region
    pfam03769
    Location:101 → 220
    Attacin_C; Attacin, C-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45884.1 P45884
Q95NP8 Q95NP8
Q95SX2 Q95SX2
Q95U97 Q95U97
Q95U98 Q95U98
Q95U99 Q95U99
Q95UA0 Q95UA0
Q95UA1 Q95UA1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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