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IPP intracisternal A particle-promoted polypeptide [ Homo sapiens (human) ]

Gene ID: 3652, updated on 5-Mar-2024

Summary

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Official Symbol
IPPprovided by HGNC
Official Full Name
intracisternal A particle-promoted polypeptideprovided by HGNC
Primary source
HGNC:HGNC:6108
See related
Ensembl:ENSG00000197429 MIM:147485; AllianceGenome:HGNC:6108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLHL27
Summary
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 2.7), testis (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45694324..45750653, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45566668..45627842, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46159996..46216325, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1 like 1 Neighboring gene ribosomal protein S15a pseudogene 10 Neighboring gene ribosomal protein L7a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46142481-46142981 Neighboring gene Sharpr-MPRA regulatory region 13545 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46151821-46152419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 987 Neighboring gene transmembrane protein 69 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 834 Neighboring gene uncharacterized LOC105378693 Neighboring gene ribosomal protein L6 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein. Kim IF, et al. Gene, 1999 Mar 4. PMID 10072760
  2. The IPP gene is assigned to human chromosome 1p32-1p22. Chang-Yeh A, et al. Genomics, 1993 Jan. PMID 8432546
  3. Identification of a novel murine IAP-promoted placenta-expressed gene. Chang-Yeh A, et al. Nucleic Acids Res, 1991 Jul 11. PMID 1906605, Free PMC Article
  4. Cell lineage-specific expression of the MIPP gene. Mold DE, et al. Biochem Biophys Res Commun, 1991 Jun 28. PMID 1905535
  5. MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines. Kim YC, et al. Int J Mol Sci, 2020 Jul 30. PMID 32751711, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
    Title: Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival.
  2. MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
    Title: MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
actin-binding protein IPP
Names
kelch-like family member 27
kelch-like protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145349.2 → NP_001138821.1  actin-binding protein IPP isoform 2

    See identical proteins and their annotated locations for NP_001138821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK023880, BC032544, DA905423
    Consensus CDS
    CCDS44132.1
    UniProtKB/Swiss-Prot
    Q9Y573
    Related
    ENSP00000353024.4, ENST00000359942.8
    Conserved Domains (2) summary
    PHA03098
    Location:30 → 540
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]

  2. NM_005897.3 → NP_005888.1  actin-binding protein IPP isoform 1

    See identical proteins and their annotated locations for NP_005888.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK023880, AL604028, DA905423
    Consensus CDS
    CCDS30702.1
    UniProtKB/Swiss-Prot
    A2A6V4, D3DQ11, Q8N5C3, Q9Y573
    Related
    ENSP00000379739.3, ENST00000396478.4
    Conserved Domains (2) summary
    PHA03098
    Location:30 → 575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    45694324..45750653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419673.1 → XP_047275629.1  actin-binding protein IPP isoform X2

  2. XM_006710623.5 → XP_006710686.1  actin-binding protein IPP isoform X3

    Conserved Domains (5) summary
    smart00612
    Location:392 → 437
    Kelch; Kelch domain
    smart00225
    Location:38 → 134
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:333 → 377
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:28 → 131
    BTB; BTB/POZ domain
    pfam07707
    Location:139 → 241
    BACK; BTB And C-terminal Kelch

  3. XM_024446763.2 → XP_024302531.1  actin-binding protein IPP isoform X1

    UniProtKB/Swiss-Prot
    A2A6V4, D3DQ11, Q8N5C3, Q9Y573
    Conserved Domains (2) summary
    PHA03098
    Location:30 → 575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    45566668..45627842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336421.1 → XP_054192396.1  actin-binding protein IPP isoform X2

  2. XM_054336424.1 → XP_054192399.1  actin-binding protein IPP isoform X3

  3. XM_054336420.1 → XP_054192395.1  actin-binding protein IPP isoform X1

    UniProtKB/Swiss-Prot
    A2A6V4, D3DQ11, Q8N5C3, Q9Y573

  4. XM_054336422.1 → XP_054192397.1  actin-binding protein IPP isoform X4

  5. XM_054336423.1 → XP_054192398.1  actin-binding protein IPP isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y573.1 GenPept UniProtKB/Swiss-Prot:Q9Y573

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