Damm Death associated molecule related to Mch2 caspase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dammprovided by FlyBase
Official Full Name: Death associated molecule related to Mch2 caspaseprovided by FlyBase
Primary source: FLYBASE:FBgn0033659
Locus tag: Dmel_CG18188
See related: AllianceGenome:FB:FBgn0033659
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18188; damm; DAMM; Damm/Daydream; Daydream; Dmel\CG18188
Summary: Enables cysteine-type endopeptidase activity. Involved in apoptotic process and proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including egg chamber; embryonic/larval central nervous system; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11864112..11866383, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7752681..7753888, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death	TAS Traceable Author Statement more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

Names: CG18188-PA; CG18188-PB; Damm-PA; Damm-PB; daydream; death associated molecule related to Mch2

NP_001303345.1

NP_523703.2

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The following sections contain reference sequences that belong to a specific genome build. Explain