Ggct gamma-glutamyl cyclotransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ggctprovided by RGD
Official Full Name: gamma-glutamyl cyclotransferaseprovided by RGD
Primary source: RGD:1304876
See related: Ensembl:ENSRNOG00000034084 AllianceGenome:RGD:1304876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ggctl1; RGD1304876; RGD1562590
Summary: Predicted to enable gamma-glutamylcyclotransferase activity and protein homodimerization activity. Predicted to be involved in release of cytochrome c from mitochondria. Predicted to be located in cytosol. Orthologous to human GGCT (gamma-glutamylcyclotransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 559.6), Liver (RPKM 114.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (85453387..85459597, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84122921..84129327, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85186644..85192857, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the distribution pattern of the C7orf24/gamma-glutamyl cyclotransferase mRNA in rat tissues
Title: The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gamma-glutamylcyclotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-glutamylcyclotransferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-glutamylcyclotransferase

Names: gamma-glutamyl cyclotransferase-like 1

NP_001102099.1

EC 4.3.2.9

XP_038963728.1

EC 4.3.2.9

XP_063142341.1

EC 4.3.2.9

XP_063142342.1

EC 4.3.2.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108629.2 → NP_001102099.1 gamma-glutamylcyclotransferase

See identical proteins and their annotated locations for NP_001102099.1

Status: VALIDATED

Source sequence(s)

FM060344, JAXUCZ010000004

UniProtKB/TrEMBL

A6K0W3, D3ZPV8

Related

ENSRNOP00000049903.3, ENSRNOT00000043752.5

Conserved Domains (1) summary

pfam13772
Location:78 → 160

AIG2_2; AIG2-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

85453387..85459597 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286272.1 → XP_063142342.1 gamma-glutamylcyclotransferase isoform X3
XM_063286271.1 → XP_063142341.1 gamma-glutamylcyclotransferase isoform X2

UniProtKB/TrEMBL

A6K0W5
XM_039107800.2 → XP_038963728.1 gamma-glutamylcyclotransferase isoform X1

Conserved Domains (1) summary

cd06661
Location:19 → 96

GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...