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Fkbp14 FKBP prolyl isomerase 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362366, updated on 5-Mar-2024

Summary

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Official Symbol
Fkbp14provided by RGD
Official Full Name
FKBP prolyl isomerase 14provided by RGD
Primary source
RGD:1311705
See related
Ensembl:ENSRNOG00000009886 AllianceGenome:RGD:1311705
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome kyphoscoliotic type 2. Orthologous to human FKBP14 (FKBP prolyl isomerase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 144.7), Lung (RPKM 101.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85035840..85051917, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83705531..83721515, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84753628..84768314, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene pleckstrin homology domain containing A8 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 3 Neighboring gene uncharacterized LOC134486771

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP14
Names
FK506 binding protein 14
NP_001013228.1
XP_017448176.1
XP_038963725.1
XP_063142340.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013210.1 → NP_001013228.1  peptidyl-prolyl cis-trans isomerase FKBP14 precursor

    See identical proteins and their annotated locations for NP_001013228.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083746
    UniProtKB/TrEMBL
    A0A8I6A3P9, A6K0V4, Q5XID8
    Related
    ENSRNOP00000087077.1, ENSRNOT00000119659.1
    Conserved Domains (2) summary
    pfam00254
    Location:38 → 132
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:141 → 204
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    85035840..85051917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107797.2 → XP_038963725.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X2

    UniProtKB/TrEMBL
    F7ELR6
    Related
    ENSRNOP00000013205.5
    Conserved Domains (2) summary
    COG0545
    Location:36 → 55
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam13499
    Location:61 → 124
    EF-hand_7; EF-hand domain pair

  2. XM_017592687.3 → XP_017448176.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNP3
    Related
    ENSRNOP00000079630.1

  3. XM_063286270.1 → XP_063142340.1  peptidyl-prolyl cis-trans isomerase FKBP14 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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