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Pals2 protein associated with LIN7 2, MAGUK p55 family member [ Rattus norvegicus (Norway rat) ]

Gene ID: 362359, updated on 5-Mar-2024

Summary

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Official Symbol
Pals2provided by RGD
Official Full Name
protein associated with LIN7 2, MAGUK p55 family memberprovided by RGD
Primary source
RGD:1311833
See related
Ensembl:ENSRNOG00000021579 AllianceGenome:RGD:1311833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mpp6
Summary
Predicted to be located in plasma membrane. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 115.9), Brain (RPKM 100.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pals2 in Genome Data Viewer
Location:
4q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (80504298..80584951)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (79173488..79257542)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (79846506..79928977)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene neuropeptide Y Neighboring gene uncharacterized LOC102555694 Neighboring gene basic proline-rich protein-like Neighboring gene gasdermin E Neighboring gene oxysterol binding protein-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of Pals, proteins associated with mLin-7. Kamberov E, et al. J Biol Chem, 2000 Apr 14. PMID 10753959
  2. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, et al. J Biol Chem, 2004 May 21. PMID 15024025
  3. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, et al. Wiley Interdiscip Rev RNA, 2015 Mar-Apr. PMID 25346433, Free PMC Article
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189400

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein PALS2
Names
CH474011:EDL88200
MAGUK p55 subfamily member 6
membrane palmitoylated protein 6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
protein associated with LIN7 2, MAGUK family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134982.1 → NP_001128454.1  protein PALS2

    See identical proteins and their annotated locations for NP_001128454.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169025
    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A9K3Y6Q0, B5DFE0, D3ZW03
    Related
    ENSRNOP00000037380.5, ENSRNOT00000029332.7
    Conserved Domains (6) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:219 → 279
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    smart00072
    Location:347 → 528
    GuKc; Guanylate kinase homologues
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:337 → 527
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    80504298..80584951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107787.2 → XP_038963715.1  protein PALS2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A8I6GMH8, A6K0L7
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233 → 293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  2. XM_006236496.5 → XP_006236558.1  protein PALS2 isoform X2

    See identical proteins and their annotated locations for XP_006236558.1

    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A8I6GMH8, A6K0L7
    Related
    ENSRNOP00000097400.1
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233 → 293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  3. XM_039107784.2 → XP_038963712.1  protein PALS2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A8I6GMH8, A6K0L7
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233 → 293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  4. XM_006236497.5 → XP_006236559.1  protein PALS2 isoform X2

    See identical proteins and their annotated locations for XP_006236559.1

    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A8I6GMH8, A6K0L7
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233 → 293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  5. XM_039107785.2 → XP_038963713.1  protein PALS2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A8I6GMH8, A6K0L7
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233 → 293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  6. XM_039107786.2 → XP_038963714.1  protein PALS2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A8I6GMH8, A6K0L7
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233 → 293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  7. XM_008762897.4 → XP_008761119.1  protein PALS2 isoform X2

    See identical proteins and their annotated locations for XP_008761119.1

    UniProtKB/TrEMBL
    A0A0G2K4N7, A0A8I6GMH8, A6K0L7
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12038
    Location:233 → 293
    SH3_MPP6; Src Homology 3 domain of Membrane Protein, Palmitoylated 6 (or MAGUK p55 subfamily member 6)
    cd00992
    Location:133 → 206
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:351 → 541
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:57 → 108
    L27; L27 domain

  8. XM_063286255.1 → XP_063142325.1  protein PALS2 isoform X3

  9. XM_063286256.1 → XP_063142326.1  protein PALS2 isoform X5

  10. XM_063286254.1 → XP_063142324.1  protein PALS2 isoform X1

  11. XM_039107788.2 → XP_038963716.2  protein PALS2 isoform X4

RNA

  1. XR_005503249.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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