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Abcb10 ATP binding cassette subfamily B member 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361439, updated on 11-Apr-2024

Summary

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Official Symbol
Abcb10provided by RGD
Official Full Name
ATP binding cassette subfamily B member 10provided by RGD
Primary source
RGD:1311222
See related
Ensembl:ENSRNOG00000017993 AllianceGenome:RGD:1311222
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial unfolded protein response; positive regulation of erythrocyte differentiation; and positive regulation of hemoglobin biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of mitochondrial membrane. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 245.5), Muscle (RPKM 106.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68850108..68881689, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51952655..51982910, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56742809..56772904, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene nucleoporin 133 Neighboring gene uncharacterized LOC134483405 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene TATA-box binding protein associated factor 5 like 1 Neighboring gene URB2 ribosome biogenesis homolog Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). Graf SA, et al. J Biol Chem, 2004 Oct 8. PMID 15215243
  2. M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein. Zhang F, et al. FEBS Lett, 2000 Jul 28. PMID 10922475
  3. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. Shirihai OS, et al. EMBO J, 2000 Jun 1. PMID 10835348, Free PMC Article
  4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109142

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in erythrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family B member 10, mitochondrial
Names
ATP-binding cassette, sub-family B (MDR/TAP), member 10
ATP-binding cassette, subfamily B (MDR/TAP), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012166.1 → NP_001012166.1  ATP-binding cassette sub-family B member 10, mitochondrial

    See identical proteins and their annotated locations for NP_001012166.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089900
    UniProtKB/TrEMBL
    A0A8I6ATQ1, Q5FVL8
    Related
    ENSRNOP00000024232.3, ENSRNOT00000024232.5
    Conserved Domains (3) summary
    cd03249
    Location:458 → 698
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    TIGR00958
    Location:10 → 694
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:142 → 403
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    68850108..68881689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278167.1 → XP_063134237.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

  2. XM_039097899.2 → XP_038953827.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X2

    Conserved Domains (2) summary
    cd18573
    Location:139 → 430
    ABC_6TM_ABCB10_like; Six-transmembrane helical domain (6-TMD) of the mitochondrial transporter ABCB10 (subfamily B, member 10) and similar proteins
    cl38936
    Location:458 → 521
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_063278168.1 → XP_063134238.1  ATP-binding cassette sub-family B member 10, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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