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Rad23a RAD23 homolog A, nucleotide excision repair protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 361381, updated on 13-Apr-2024

Summary

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Official Symbol
Rad23aprovided by RGD
Official Full Name
RAD23 homolog A, nucleotide excision repair proteinprovided by RGD
Primary source
RGD:1309899
See related
Ensembl:ENSRNOG00000003026 AllianceGenome:RGD:1309899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including enzyme binding activity; proteasome binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of viral genome replication; and protein destabilization. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in centriolar satellite; cytoplasm; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleoplasm. Orthologous to human RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 292.7), Spleen (RPKM 265.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rad23a in Genome Data Viewer
Location:
19q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40219235..40225543)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23313563..23320702)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25949488..25956677, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene GADD45G interacting protein 1 Neighboring gene calreticulin Neighboring gene uncharacterized LOC134483324 Neighboring gene DAN domain BMP antagonist family member 5 Neighboring gene uncharacterized LOC134483325 Neighboring gene nuclear factor I X

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. Raasi S, et al. J Biol Chem, 2003 Mar 14. PMID 12643283
  2. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Sugasawa K, et al. Mol Cell Biol, 1997 Dec. PMID 9372924, Free PMC Article
  3. Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3. Laço MN, et al. PLoS One, 2012. PMID 22970133, Free PMC Article
  4. HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome. Li G, et al. PLoS One, 2010 Jun 29. PMID 20614012, Free PMC Article
  5. hHR23A is required to control the basal turnover of Chk1. Tan X, et al. Cell Signal, 2015 Nov. PMID 26296656

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
UV excision repair protein RAD23 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013190.2 → NP_001013208.1  UV excision repair protein RAD23 homolog A isoform 1

    See identical proteins and their annotated locations for NP_001013208.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    F7FJT3, Q5XFX7
    Conserved Domains (4) summary
    cd01805
    Location:3 → 80
    RAD23_N; Ubiquitin-like domain of RAD23
    cd14377
    Location:162 → 201
    UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
    TIGR00601
    Location:3 → 325
    rad23; UV excision repair protein Rad23
    pfam09280
    Location:231 → 286
    XPC-binding; XPC-binding domain

  2. NM_001399101.1 → NP_001386030.1  UV excision repair protein RAD23 homolog A isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6IY71
    Conserved Domains (1) summary
    TIGR00601
    Location:3 → 361
    rad23; UV excision repair protein Rad23

  3. NM_001399102.1 → NP_001386031.1  UV excision repair protein RAD23 homolog A isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    Related
    ENSRNOP00000004042.5, ENSRNOT00000004042.6
    Conserved Domains (1) summary
    TIGR00601
    Location:3 → 360
    rad23; UV excision repair protein Rad23

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    40219235..40225543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772411.4 → XP_008770633.1  UV excision repair protein RAD23 homolog A isoform X1

    UniProtKB/TrEMBL
    F7FJT3
    Conserved Domains (4) summary
    cd01805
    Location:3 → 80
    RAD23_N; Ubiquitin-like domain of RAD23
    smart00213
    Location:3 → 77
    UBQ; Ubiquitin homologues
    cd14377
    Location:162 → 201
    UBA1_Rad23; UBA1 domain of Rad23 proteins found in metazoa
    pfam09280
    Location:232 → 287
    XPC-binding; XPC-binding domain

RNA

  1. XR_010060012.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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