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CG7220 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36129, updated on 26-Apr-2024

Summary

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Official Symbol
CG7220provided by FlyBase
Primary source
FLYBASE:FBgn0033544
Locus tag
Dmel_CG7220
See related
AllianceGenome:FB:FBgn0033544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH28095; BEST:GH28095; Dmel\CG7220; Ube2W
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein monoubiquitination; and protein polyubiquitination. Predicted to be active in nucleus. Is expressed in adult fat body and eye. Orthologous to human UBE2W (ubiquitin conjugating enzyme E2 W). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
47B7-47B9; 2-63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10731335..10738370)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6618840..6625875)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene starry night Neighboring gene Rab3 Neighboring gene Carbonic anhydrase 13 Neighboring gene D-amino acid oxidase 1 Neighboring gene uncharacterized protein Neighboring gene Menage a trois 1 Neighboring gene long non-coding RNA:CR43605

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect. Champer J, et al. Genetics, 2019 May. PMID 30918006, Free PMC Article
  2. The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs. Zhang Y, et al. Elife, 2016 Oct 3. PMID 27692068, Free PMC Article
  3. The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster. Tsou WL, et al. Neurobiol Dis, 2015 Oct. PMID 26007638, Free PMC Article
  4. Isolation of mRNA from specific tissues of Drosophila by mRNA tagging. Yang Z, et al. Nucleic Acids Res, 2005 Oct 4. PMID 16204451, Free PMC Article
  5. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7220-PA
CG7220-PB
CG7220-PC
CG7220-PD
CG7220-PE
CG7220-PF
NP_001097261.1
NP_001286293.1
NP_610604.3
NP_724964.2
NP_724965.2
NP_995809.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10731335..10738370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136760.4 → NP_610604.3  uncharacterized protein Dmel_CG7220, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610604.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T972
    Related
    FBpp0087311
    Conserved Domains (1) summary
    pfam00179
    Location:10 → 151
    UQ_con; Ubiquitin-conjugating enzyme

  2. NM_206087.3 → NP_995809.1  uncharacterized protein Dmel_CG7220, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995809.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T972
    Conserved Domains (1) summary
    pfam00179
    Location:10 → 151
    UQ_con; Ubiquitin-conjugating enzyme

  3. NM_165796.3 → NP_724965.2  uncharacterized protein Dmel_CG7220, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724965.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T972
    Related
    FBpp0087312
    Conserved Domains (1) summary
    pfam00179
    Location:10 → 151
    UQ_con; Ubiquitin-conjugating enzyme

  4. NM_001103791.2 → NP_001097261.1  uncharacterized protein Dmel_CG7220, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097261.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8B5, A8DY96, D3DMQ0
    Conserved Domains (1) summary
    pfam00179
    Location:46 → 187
    UQ_con; Ubiquitin-conjugating enzyme

  5. NM_001299364.1 → NP_001286293.1  uncharacterized protein Dmel_CG7220, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286293.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8B5, A8DY96, D3DMQ0
    Conserved Domains (1) summary
    pfam00179
    Location:46 → 187
    UQ_con; Ubiquitin-conjugating enzyme

  6. NM_165795.4 → NP_724964.2  uncharacterized protein Dmel_CG7220, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724964.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8B5, A8DY96, D3DMQ0
    Conserved Domains (1) summary
    pfam00179
    Location:46 → 187
    UQ_con; Ubiquitin-conjugating enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8B5 A1Z8B5
Q8T972 Q8T972
Q95SG1 Q95SG1

Gene LinkOut

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