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Mllt10 MLLT10, histone lysine methyltransferase DOT1L cofactor [ Rattus norvegicus (Norway rat) ]

Gene ID: 361285, updated on 3-Apr-2024

Summary

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Official Symbol
Mllt10provided by RGD
Official Full Name
MLLT10, histone lysine methyltransferase DOT1L cofactorprovided by RGD
Primary source
RGD:1310874
See related
Ensembl:ENSRNOG00000022249 AllianceGenome:RGD:1310874
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in histone H3-K14 acetylation and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 213.6), Thymus (RPKM 134.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.3
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (85729964..85857791)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (80821870..80949349)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (84847660..84981134)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553115 Neighboring gene uncharacterized LOC108353137 Neighboring gene SKI/DACH domain containing 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene uncharacterized LOC108348596 Neighboring gene uncharacterized LOC134482756

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Chaplin T, et al. Blood, 1995 Sep 15. PMID 7662954
  2. AF10-dependent transcription is enhanced by its interaction with FLRG. Forissier S, et al. Biol Cell, 2007 Oct. PMID 17868029
  3. hDOT1L links histone methylation to leukemogenesis. Okada Y, et al. Cell, 2005 Apr 22. PMID 15851025
  4. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Chen S, et al. Mol Cell, 2015 Oct 15. PMID 26439302, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein AF-10
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
translocated to, 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012162.1 → NP_001012162.1  protein AF-10

    See identical proteins and their annotated locations for NP_001012162.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087128
    UniProtKB/TrEMBL
    F1M8I4, Q5PQL6
    Related
    ENSRNOP00000093341.1, ENSRNOT00000107584.1
    Conserved Domains (1) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    85729964..85857791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095942.2 → XP_038951870.2  protein AF-10 isoform X1

  2. XM_063276642.1 → XP_063132712.1  protein AF-10 isoform X2

  3. XM_063276654.1 → XP_063132724.1  protein AF-10 isoform X15

  4. XM_063276655.1 → XP_063132725.1  protein AF-10 isoform X16

  5. XM_063276643.1 → XP_063132713.1  protein AF-10 isoform X3

  6. XM_063276647.1 → XP_063132717.1  protein AF-10 isoform X7

  7. XM_063276648.1 → XP_063132718.1  protein AF-10 isoform X8

  8. XM_063276644.1 → XP_063132714.1  protein AF-10 isoform X4

  9. XM_063276652.1 → XP_063132722.1  protein AF-10 isoform X12

  10. XM_063276657.1 → XP_063132727.1  protein AF-10 isoform X19

  11. XM_063276658.1 → XP_063132728.1  protein AF-10 isoform X20

  12. XM_039095945.2 → XP_038951873.1  protein AF-10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZKY6, A0A8I5ZT80
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:717 → 780
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  13. XM_039095941.2 → XP_038951869.1  protein AF-10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZKY6, A0A8I5ZT80
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:717 → 780
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  14. XM_039095947.2 → XP_038951875.1  protein AF-10 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZT80
    Related
    ENSRNOP00000081577.1
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 203
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:685 → 748
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  15. XM_039095944.2 → XP_038951872.1  protein AF-10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZKY6, A0A8I5ZT80
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:717 → 780
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  16. XM_039095948.2 → XP_038951876.1  protein AF-10 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZT80
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd20901
    Location:662 → 725
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:81 → 151
    PHD_SF; PHD finger superfamily

  17. XM_063276646.1 → XP_063132716.1  protein AF-10 isoform X6

  18. XM_063276649.1 → XP_063132719.1  protein AF-10 isoform X9

  19. XM_039095943.2 → XP_038951871.1  protein AF-10 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZKY6, A0A8I5ZT80
    Conserved Domains (3) summary
    cd15574
    Location:24 → 71
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15708
    Location:78 → 206
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:717 → 780
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  20. XM_063276656.1 → XP_063132726.1  protein AF-10 isoform X18

  21. XM_039095950.2 → XP_038951878.1  protein AF-10 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZK97, F1M8I4
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  22. XM_063276651.1 → XP_063132721.1  protein AF-10 isoform X11

    UniProtKB/TrEMBL
    A0A8I6GKM2

  23. XM_039095957.2 → XP_038951885.1  protein AF-10 isoform X14

    UniProtKB/TrEMBL
    F1M8I4
    Conserved Domains (2) summary
    cd20901
    Location:584 → 647
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:3 → 73
    PHD_SF; PHD finger superfamily

  24. XM_063276653.1 → XP_063132723.1  protein AF-10 isoform X14

  25. XM_039095955.2 → XP_038951883.1  protein AF-10 isoform X13

    UniProtKB/TrEMBL
    A6JM89, F1M8I4
    Conserved Domains (2) summary
    cd20901
    Location:598 → 661
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 87
    PHD_SF; PHD finger superfamily

  26. XM_039095960.2 → XP_038951888.1  protein AF-10 isoform X17

    UniProtKB/TrEMBL
    F1M8I4
    Conserved Domains (2) summary
    cd20901
    Location:563 → 626
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:1 → 52
    PHD_SF; PHD finger superfamily

  27. XM_063276650.1 → XP_063132720.1  protein AF-10 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZK97

  28. XM_039095959.2 → XP_038951887.1  protein AF-10 isoform X14

    UniProtKB/TrEMBL
    F1M8I4
    Conserved Domains (2) summary
    cd20901
    Location:584 → 647
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    cl22851
    Location:3 → 73
    PHD_SF; PHD finger superfamily

  29. XM_039095952.2 → XP_038951880.1  protein AF-10 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZK97, F1M8I4
    Related
    ENSRNOP00000033877.6
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins

  30. XM_039095953.2 → XP_038951881.1  protein AF-10 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZK97, F1M8I4
    Conserved Domains (2) summary
    cd15708
    Location:3 → 128
    ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    cd20901
    Location:639 → 702
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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