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Gkap1 G kinase anchoring protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361202, updated on 3-Apr-2024

Summary

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Official Symbol
Gkap1provided by RGD
Official Full Name
G kinase anchoring protein 1provided by RGD
Primary source
RGD:1306955
See related
Ensembl:ENSRNOG00000019272 AllianceGenome:RGD:1306955
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of insulin receptor signaling pathway and signal transduction. Predicted to be located in Golgi apparatus. Orthologous to human GKAP1 (G kinase anchoring protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 891.0), Muscle (RPKM 170.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gkap1 in Genome Data Viewer
Location:
17p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (6389377..6429091)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (6383963..6423684)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (6785428..6825145)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene kinesin family member 27 like 1 Neighboring gene kinesin family member 27 Neighboring gene uncharacterized LOC134482805 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family Neighboring gene ubiquilin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes. Ando Y, et al. J Biol Chem, 2015 Feb 27. PMID 25586176, Free PMC Article
  2. Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. Yuasa K, et al. J Biol Chem, 2000 Feb 18. PMID 10671526
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G kinase-anchoring protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012160.1 → NP_001012160.1  G kinase-anchoring protein 1

    See identical proteins and their annotated locations for NP_001012160.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083717
    UniProtKB/Swiss-Prot
    Q5XIG5
    Related
    ENSRNOP00000026070.6, ENSRNOT00000026070.7
    Conserved Domains (1) summary
    COG1196
    Location:217 → 349
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    6389377..6429091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276552.1 → XP_063132622.1  G kinase-anchoring protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QDT6

  2. XM_063276553.1 → XP_063132623.1  G kinase-anchoring protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8L2RA95
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIG5.1 GenPept UniProtKB/Swiss-Prot:Q5XIG5

Gene LinkOut

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